DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42235 and Slc5a7

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_071308.2	Gene:	Slc5a7 / 63993	MGIID:	1927126	Length:	580	Species:	Mus musculus

Alignment Length:	489	Identity:	109/489 - (22%)
Similarity:	210/489 - (42%)	Gaps:	76/489 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 GIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGGRQMKV 167
            |:|..::|..::   .::|.:..:      |.|.:|..       |||  |||:  :||||.:.:
Mouse     7 GLVAIILFYLLI---FLVGIWAAW------KTKNSGNP-------EER--SEAI--IVGGRDIGL 51

  Fly   168 FPVALSLVASFVSGISLLGTSTEIYVYGTQYAFILVTL--AISGAISWYIFLPVFCNLQLTSTYE 230
            .....::.|::|.|..:.||:..:|..|...|:....:  ::|..:....|.....:....:..:
Mouse    52 LVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLD 116

  Fly   231 YFERRFDRRVRIFGSCLFV---VMNILWQPICIYVPALTLNQVSGISVSKIVPVTSFICILYTSV 292
            .|::.:.:|:   |..||:   :..:.|..........|::.:..:.|:..|.|::.|.||||.|
Mouse   117 PFQQIYGKRM---GGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIVSALIAILYTLV 178

  Fly   293 GGIKGVVWTDVIQ-GTVMIGSMLIVII----KGTLDLGGLSVVLDHNRQYDRLVGPDMTFDPTAR 352
            ||:..|.:|||:| ..:.||..:.|..    ....|:|..:|   |.:.....:|...:.:....
Mouse   179 GGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIGFTAV---HAKYQSPWLGTIESVEVYTW 240

  Fly   353 MGVFALFVGGALFKLQANGIN-QAIVQRYLTLPNNKDVKKALVLSLI---GFMFVMLMCVYIGLL 413
            :..|.|        |...||. ||..||.|   ::.....|.|||.:   |.:.:.|..:.||.:
Mouse   241 LDNFLL--------LMLGGIPWQAYFQRVL---SSSSATYAQVLSFLAAFGCLVMALPAICIGAI 294

  Fly   414 AFA------EFYHCDPITTGLARAKDQVIPLYVVKNVGHIPGLVGLFVAGVFSAA-LSSLSTALN 471
            ..:      .:.:.||.|...|   |.::|: |::.:  .|..:..|..|..||| :||..:::.
Mouse   295 GASTDWNQTAYGYPDPKTKEEA---DMILPI-VLQYL--CPVYISFFGLGAVSAAVMSSADSSIL 353

  Fly   472 SLSGVILTDFVEPFRKKPLTERQTAYLLRGVVISFGLISMASVPIVQRLGLVMQLSSTVAAITCG 536
            |.|.:...:..:...::..::::..:::|..|:.||..:.|...:.:.:..:..|||.:..|...
Mouse   354 SASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLWYLSSDLVYIIIF 418

  Fly   537 PLLGAFSVGMLLPFVKTESLLTGISCASSFTAYI 570
            |.|      :.:.|:|      |.:...:...||
Mouse   419 PQL------LCVLFIK------GTNTYGAVAGYI 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	108/487 (22%)
Slc5a7	NP_071308.2	SLC5sbd_CHT	8..495	CDD:271368	108/488 (22%)
Slc5a7	NP_071308.2	Mediates interaction with SEC14L1. /evidence=ECO:0000250\|UniProtKB:Q9JMD7	502..580
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836583
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740