DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42235 and slc5a6a

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_001020700.2	Gene:	slc5a6a / 563356	ZFINID:	ZDB-GENE-041001-177	Length:	625	Species:	Danio rerio

Alignment Length:	632	Identity:	197/632 - (31%)
Similarity:	317/632 - (50%)	Gaps:	70/632 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 HFGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGGRQM 165
            ||..|||::|:.:|...|.||.|:.|...:|:..:                     ::|:..|.|
Zfish     8 HFSTVDYVIFVVLLVASAGIGLYYAFSGGRQRTTQ---------------------EFLLADRSM 51

  Fly   166 KVFPVALSLVASFVSGISLLGTSTEIYVYGTQYAFILVTLAISGAISWYIFLPVFCNLQLTSTYE 230
            :..||:|||:|:|.|.:::||..:|||.|||||.|:..:..:...|..:||:|||..|:|:|.||
Zfish    52 RCLPVSLSLLATFQSAVAILGAPSEIYTYGTQYWFLGCSYFLGLLIPAHIFIPVFYRLRLSSAYE 116

  Fly   231 YFERRFDRRVRIFGSCLFVVMNILWQPICIYVPALTLNQVSGISVSKIVPVTSFICILYTSVGGI 295
            |.|.||.:.|||.|:..|:...:::..:.:|.|||.||.|:|..:...|.....:|.|||::||:
Zfish   117 YLELRFSKSVRICGTVTFIFQMVIYMGVVLYAPALALNAVTGFDLWGAVLAMGLVCTLYTALGGL 181

  Fly   296 KGVVWTDVIQGTVMIGSMLIVIIKGTLDLGGLSVVLDHNRQYDRLVGPDMTFDPTARMGVFALFV 360
            |.|:||||.|..||....|.||:.||...||::.|....:...|:.|.|:..||..|...:.|.|
Zfish   182 KAVIWTDVFQTIVMFAGQLAVIVVGTHQAGGIAEVWRKAQNGSRIAGLDLNPDPLERHTFWTLGV 246

  Fly   361 GGALFKLQANGINQAIVQRYLTLPNNKDVKKALVLSLIGF---MFVMLMCVYIGLLAFAEFYHCD 422
            ||....|...|:|||.|||||   :::..|:|::.....|   ..|:.:...:||:.:|.:....
Zfish   247 GGVFLMLALYGVNQAQVQRYL---SSRTEKEAIMSCYAVFPCQQVVLTLGCLMGLVMYARYGEES 308

  Fly   423 PITTGLARAKDQVIPLYVVKNV-GHIPGLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEPFR 486
            |:..|.....||:: ||:|.:| ..:|||.|||||.:||.|||::|:|.|||:.|.:.|.::| .
Zfish   309 PLDQGYVTTNDQMV-LYLVMDVLRDLPGLPGLFVACLFSGALSTISSAFNSLATVTMEDLIKP-H 371

  Fly   487 KKPLTERQTAYLLRGVVISFGLISMASVPIVQRLGLVMQLSSTVAAITCGPLLGAFSVGMLLPFV 551
            ...:||.:...|.:.:.:::||:.:|...|...:|.|:|.:.::..:..|||||.|.:||..|:.
Zfish   372 VPAMTEARATLLSKMLALAYGLVCLAMAYIASLMGSVLQAALSIFGMVGGPLLGLFCLGMFFPWA 436

  Fly   552 KTESLLTGISCASSFTAYIVVRAQIAIFTGSLTFPAKPVSIQDCDYTFDLPANWNAT-------T 609
            .:...|.|::.......:|    .|..|...::..|.||    .:.|. :|...|.|       |
Zfish   437 NSTGALVGLASGLVMAFWI----GIGSFVSRMSLSALPV----INATI-IPDVGNMTTAVMTTLT 492

  Fly   610 TATPTESTSHGIHEISFLWYTAVGSVGTVLGSLLATLYFGRQDPRVVDKELISPVLRK---FWYG 671
            |..|..|....::.:|::||:|..|...|:..|:.:...|....:.::...:.|||..   |...
Zfish   493 TTKPRPSGVQALYSLSYMWYSAHNSATVVVVGLVVSFLTGPWKEKDLNPGTVYPVLGNLLFFLPQ 557

  Fly   672 KYES---------------------VASEEKNNFNLHESETQLKLEQ 697
            :|..                     :|.:|.|.....:.|.:|:.|:
Zfish   558 RYREKLCCVTPLEDKSKDLDRQPYRMAQKESNGVACTKEEDKLREEE 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	183/551 (33%)
slc5a6a	NP_001020700.2	SLC5-6-like_sbd	9..532	CDD:294310	184/557 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820