DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42235 and slc5a5

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_001082860.1	Gene:	slc5a5 / 561445	ZFINID:	ZDB-GENE-060503-585	Length:	601	Species:	Danio rerio

Alignment Length:	582	Identity:	182/582 - (31%)
Similarity:	303/582 - (52%)	Gaps:	55/582 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 FGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGGRQMK 166
            |.:|||.||.|||.|...||.:       |..:|..|:             |:...:..|||...
Zfish    11 FCLVDYAVFAAMLGVSVGIGLF-------QSLRKTPGR-------------SKVDSFFTGGRGFS 55

  Fly   167 VFPVALSLVASFVSGISLLGTSTEIYVYGTQYAFILVTLAISGAISWYIFLPVFCNLQLTSTYEY 231
            ..||.|||.|||:|.:.:||..:|.|:||.::.::.:...::..::..:|:|||..|::||:.:|
Zfish    56 AVPVGLSLCASFMSAVQVLGVPSETYLYGFKFLYMCLGQGLNSLMTAVLFVPVFYRLKITSSSQY 120

  Fly   232 FERRFDRRVRIFGSCLFVVMNILWQPICIYVPALTLNQVSGISVSKIVPVTSFICILYTSVGGIK 296
            ...||.|.:::.||..|:|..:|:..|.|:.||:.|||.:|:::...:..|..||..||:|||:|
Zfish   121 LGMRFGRGMQLLGSLQFIVATLLYTGIVIFAPAVILNQATGLNMWASLFSTGLICTFYTTVGGMK 185

  Fly   297 GVVWTDVIQGTVMIGSMLIVIIKGTLDLGGLSVVLDHNRQYDRLVGPDMTFDPTARMGVFALFVG 361
            .|:||||.|..||:...:.|.|:||:..||.:.||:......|:...|...||..|...::..||
Zfish   186 AVIWTDVFQIVVMLSGFIAVFIQGTILAGGPARVLEIANNGSRINFNDFAIDPQRRYSFWSFTVG 250

  Fly   362 GALFKLQANGINQAIVQRYLTLPNNKDVKKALVLSLIGFMFVMLMCVYIGLLAFAEFYHCDPITT 426
            |.:..|...|.|||.||||::....|..:.||:::.:|...::......|::.||.:.:|||:..
Zfish   251 GTMVWLSMYGANQAQVQRYISCRTEKQAQLALLVNQVGLCLIVSSAATCGIVMFALYSNCDPLKI 315

  Fly   427 GLARAKDQVIPLYVVKNVGHIPGLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEPFRKKPLT 491
            |...|.||.:|..|:....:.||..|||:|..:|..||::||::|:::.|.:.|.::|: ...::
Zfish   316 GRISAPDQYMPYLVLDIFRNHPGFPGLFLACAYSGTLSTVSTSINAMAAVTMEDVMKPW-LITIS 379

  Fly   492 ERQTAYLLRGVVISFGL--ISMASVPIVQRLGLVMQLSSTVAAITCGPLLGAFSVGMLLPFVKTE 554
            :|:...|.|.:.:.:||  |:||::..:...| |:|.|.||..:..|||||||::||.:|.....
Zfish   380 QRKQLMLSRALSLFYGLGCITMAALSSLLDWG-VLQGSFTVMGVVNGPLLGAFALGMFVPATNKP 443

  Fly   555 SLLTGISCASSFTAYIVVRAQIAIFTGSLTFPAK-------PVSIQDCDYTFDLPANWNATTTAT 612
            .:.:|::.....:.::.|        ||..:|..       |.|...|     |..|....|||:
Zfish   444 GVFSGVAVGFCLSLWLAV--------GSTIYPPSPQIMGVLPTSAGQC-----LTTNATLNTTAS 495

  Fly   613 ------PTESTSHGIHEISFLWYTAVGSVGTVLGSLLATLYFGRQDPRVVDKELISPVLRKF 668
                  |.:.:...|:.||:|::.|:.:...||..::.:...|     ...|:.|||.|.::
Zfish   496 VLASSVPLDYSFQNIYSISYLYFGALSTSAVVLVGVVVSYITG-----PTKKDSISPGLLRW 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	175/555 (32%)
slc5a5	NP_001082860.1	SLC5-6-like_sbd	14..549	CDD:320982	180/574 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580098
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950