DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42235 and CG2187

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	627	Identity:	198/627 - (31%)
Similarity:	322/627 - (51%)	Gaps:	62/627 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 SSTPTTSTTFAYTPTPTPTQSASPSLEDGEEKLSVKDLSQALQHFGIVDYLVFIAMLAVCAVIGF 122
            |:|.||:||.|     :...|||..|                 .||:.||.||:.||...|.||.
  Fly     2 STTTTTTTTMA-----SAVSSASQDL-----------------RFGLTDYFVFVIMLGASAGIGV 44

  Fly   123 YFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGGRQMKVFPVALSLVASFVSGISLLGT 187
            ||||..|.:...:                     :||.||::|:..|:|:|||||.:|||:::..
  Fly    45 YFGFFSKSKNTTE---------------------EYLRGGKKMQTLPIAISLVASQLSGIAIMSI 88

  Fly   188 STEIYVYGTQYAFILVTLAISGAISWYIFLPVFCNLQLTSTYEYFERRFDRRVRIFGSCLFVVMN 252
            ..|.|.||..|.|:::.:.:...|..||.:|||....:::.|||.|.||::|.|...:..||..:
  Fly    89 PAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTNS 153

  Fly   253 ILWQPICIYVPALTLNQVSGISVSKIVPVTSFICILYTSVGGIKGVVWTDVIQGTVMIGSMLIVI 317
            .|..|:.:::|:|...||:|:::..|..:.|.|||.||.:||||.||||||:||.:|:.|::.|.
  Fly   154 FLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVG 218

  Fly   318 IKGTLDLGGLSVVLDHNRQYDRLVGPDMTFDPTARMGVFALFVGGALFKLQANGINQAIVQRYLT 382
            :.||:..||:..|::......|. ..|...||..||..:...:||........|:||:.|||.::
  Fly   219 VLGTIRSGGMFTVMERASDGGRF-NFDFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIVS 282

  Fly   383 LPNNKDVKKALVLSLIGFMFVMLMCVYIGLLAFAEFYHCDPITTGLARAKDQVIPLYVVKNVGHI 447
            ||:....||:|::|.:||:.:.......|::.||.:|.|||:..||....|:::|.:|...:||:
  Fly   283 LPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFVQDIMGHL 347

  Fly   448 PGLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEPFRKKPLTERQTAYLLRGVVISFGLISMA 512
            .|:.|:|::.||||||||||..||||:||:..|:::|..:.  ||.:..:.::.:|:..|...:.
  Fly   348 AGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRH--TEARANWAMKLIVVVMGGYCIL 410

  Fly   513 SVPIVQRLGLVMQLSSTVAAITCGPLLGAFSVGMLLPFVKTESLLTGISCASSFTAYIVVRAQIA 577
            ...:||....::|...|:..|..|.::|.|.:||.:|....::.:|.|..:.....:|:...|:.
  Fly   411 GGFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWIIANGQMN 475

  Fly   578 IFTGSLTFPAKPVSIQDCD----YTFDLPANWNATTTAT-------PTESTSH-----GIHEISF 626
            ..:|.:.:...|.|:..|:    |......|....|..|       |..:..|     .:::|||
  Fly   476 FKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRDFSLYDISF 540

  Fly   627 LWYTAVGSVGTVLGSLLATLYFGRQDPRVVDKELISPVLRKF 668
            .||..:||....|.::..:..:...:....:.:|.||.:|||
  Fly   541 YWYKVLGSALVFLCAIPLSYIWRPDENEKQNPKLYSPFVRKF 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	179/556 (32%)
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	179/557 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448230
Domainoid	1	1.000	74	1.000	Domainoid score	I2508
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900