DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42235 and CG7720

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_001163649.1	Gene:	CG7720 / 42257	FlyBaseID:	FBgn0038652	Length:	681	Species:	Drosophila melanogaster

Alignment Length:	643	Identity:	175/643 - (27%)
Similarity:	300/643 - (46%)	Gaps:	89/643 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 DYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGGRQMKVFPV 170
            |||:|:..:|: .|:|..:..|..|:|::..|                   ||:.....:.:..|
  Fly    11 DYLMFVLFIAL-TVLGPLWKRIFGKKKERSKA-------------------DYVFATGGVSIVAV 55

  Fly   171 ALSLVASFVSGISLLGTSTEIYVYGTQYAFILVTLAISGAISWYIFLPVFCNLQLTSTYEYFERR 235
            .:|:....:...|:||..:|:|..|:....|:..:..:..|..::|:||:.||.:||.|:|.:.|
  Fly    56 MISIARGTLGVRSVLGYPSELYYRGSAMWEIIYGMMSAYPIVCFMFVPVYFNLGITSVYQYIDLR 120

  Fly   236 F-DRRVRIFGSCLFVVMNILWQPICIYVPALTLNQVSGISVSKIVPVTSFICILYTSVGGIKGVV 299
            | .|.||...|..::|..|....|.:|.|::.|:.|.||.....:...:.|||.:|.:||:|..:
  Fly   121 FKSRTVRCLASATYIVRQICNLGITVYTPSVALSTVIGIPYWASITGMAVICIFFTIMGGLKAAI 185

  Fly   300 WTDVIQGTVMIGSMLIVIIKGTLDLGGLSVVLDHNRQYDRLVGPDMTFDPTARMGVFALFVGGAL 364
            ..||||...::...:.|.|:||:..||:..|...||...||...:.|.|.|.|:...:.::|...
  Fly   186 NADVIQTVTILVVTVAVCIQGTISTGGVKKVYQLNRDNGRLNFWNFTGDMTVRVDTTSAWLGQLF 250

  Fly   365 FKLQANGINQAIVQRYLTLPNNKDVKKALVLSLIGFMFVMLMCVYIGLLAFAEFYHCDPITTGLA 429
            ..|...|..|..:|||::|.:.|.|::.::.::....|...:....|::.::.:.:|||...|..
  Fly   251 MSLSQIGCQQNFMQRYVSLKSLKQVRRVMLTNVPLVFFFFSISWISGMVIYSTYINCDPYAEGYI 315

  Fly   430 RAKDQVIPLYVVKNVGHIPGLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEPFRK-KPLTER 493
            :..|:::|.:|...:|.:||.||:|:|.:|:.||..:.:.||||:.||..||:....| |.|:::
  Fly   316 KKPDEILPFFVEDQLGFLPGFVGIFMATLFNGALCMMVSNLNSLATVIWEDFISQLPKFKGLSDK 380

  Fly   494 QTAYLLRGVVISFGLISMASVPIVQRLGLVMQLSSTVAAITCGPLLGAFSVGMLLPFVKTESLLT 558
            |...:|:.:.:..|||.|.....|..|..|::.|..|.:.|.|||||.|.:.|::|....:....
  Fly   381 QQLRILKSITVVCGLIIMGVAFGVGLLAGVIESSLLVFSATSGPLLGCFILAMMVPIANWKGTSA 445

  Fly   559 GISCASSFTAYIVVRAQIAIFTGSLTF----PAKPVSIQDC-DYTF------------DLPANW- 605
            |:..|.:|..:|:        .|.:|.    |..|.|...| :.||            .:|  |
  Fly   446 GMVTACAFVLWII--------GGGMTVTKDNPLLPTSTDGCTNDTFAQSIGKPIVEQGQMP--WL 500

  Fly   606 --------------NATTTATPTESTSHGIHEISFLWYTAVGSVGTV-LGSLLATLYFGRQDP-R 654
                          ....|..|..|.....:.|||::|:.:|:..|| :|::::.|   .|.| .
  Fly   501 LSHTPIDGFNQSFVPTQPTIAPERSGLETFYSISFMYYSLIGTALTVIIGTVISLL---TQHPDD 562

  Fly   655 VVDKELISPVL---------RKFWYGKYESVASEEKNNFNLHESE------TQLKLEQ 697
            ..|.:|:.|::         ||.:|.|:     ||::..|...|.      |..|.|:
  Fly   563 AYDGKLLHPLIFRLCERFSGRKPYYVKH-----EEESGLNGRSSSDSSATTTTCKAEK 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	158/574 (28%)
CG7720	NP_001163649.1	SLC5sbd_NIS-SMVT	10..556	CDD:271383	158/574 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I385
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.970