DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42235 and CG10444

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	625	Identity:	190/625 - (30%)
Similarity:	309/625 - (49%)	Gaps:	79/625 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 FGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGGRQMK 166
            |...|..|.|.:|.:.|:||.|:.:...|||..:                     :||:..:.|.
  Fly     6 FDAWDAAVLITILVISALIGIYYRYTGGKQKTTQ---------------------EYLMADQSMT 49

  Fly   167 VFPVALSLVASFVSGISLLGTSTEIYVYGTQYAFILVTLAISGAISWYIFLPVFCNLQLTSTYEY 231
            .|||:.||:|||:|.|||:|.|.|.|.:||.:..|.:...:|..|:.|.|||||..::.||.|||
  Fly    50 TFPVSFSLMASFMSAISLMGVSNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEY 114

  Fly   232 FERRFDRRVRIFGSCLFVVMNILWQPICIYVPALTLNQVSGISVSKIVPVTSFICILYTSVGGIK 296
            .||||.:..|:..|..|.|..:|:..|.:|.|||.|..|:||..|..:.|...:|..|:::||:|
  Fly   115 LERRFGQATRLSASLAFTVQMVLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLK 179

  Fly   297 GVVWTDVIQGTVMIGSMLIVIIKGTLDLGGLSVVLDHNRQYDRLVGPDMTFDPTARMGVFALFVG 361
            .|:.|||.|..:|..::..||....:..||.:.:.|...:..|:...:.:.|||.|...::|.:|
  Fly   180 AVLITDVFQSFLMFAAIYAVIAVSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTVRHTWWSLIIG 244

  Fly   362 GALFKLQANGINQAIVQRYLTLPNNKDVKKAL-----VLSLIGFMFVMLMCVYIGLLAFAEFYHC 421
            |.:..|...|:||..|||.|::.|.|..:.||     :|.::.|     ..::.||..|..:..|
  Fly   245 GMVTYLSLYGVNQTQVQRLLSVRNLKSAQSALWWNLPILGMLSF-----STIFSGLSIFYYYRDC 304

  Fly   422 DPITTGLARAKDQVIPLYVVKNVGHIPGLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEPFR 486
            ||:..|....:||::||:.::.:|..|||.||||:|:|||:||::|:|:.|||.|.|.|:::|..
  Fly   305 DPLLKGRIDKRDQIMPLFALETMGQYPGLCGLFVSGIFSASLSTISSAVTSLSAVTLEDYLKPLY 369

  Fly   487 ----KKPLTERQTAYLLRGVVISFGLISMASVPIVQRLGLVMQLSSTVAAITCGPLLGAFSVGML 547
                |:.|.:.::....:.|...|||:.:....:...:|.|:|.|.|:..:..||||..|::|:.
  Fly   370 KAIFKRTLIDSKSTMPTKIVACIFGLLCIGLAFVAGSMGGVLQASLTIFGVVGGPLLAIFTLGVC 434

  Fly   548 LPFVKTESLLTGISCASSFTAYIVVRAQIAIFTGSLTFPAKPVSIQDCDYTFDLPANWNATTT-- 610
            ........:|.|          .:|...::.:.|......|||:::     |......|||..
  Fly   435 TTRSNQRGVLLG----------FLVSLIVSFWMGFGGPKPKPVTLE-----FSTAGCENATAVMA 484

  Fly   611 -ATPTESTSHGI---------HEISFLWYTAVG-SVGTVLG--SLLATLYFGR---------QDP 653
             |....|.|.|:         :.||:||.:.:| .:..|:|  |.:...:.|:         :..
  Fly   485 RAIELSSKSSGVVIEPDYFWLYRISYLWLSVIGFLIAVVVGYFSSIVLAHCGKAENAEIYLDKSR 549

  Fly   654 RVVDKELISPVLRKFWYGKYESVASEEKNNFNLHESETQL 693
            :.:|.:|.:|:|.:.|...     .||::.....|:.|:|
  Fly   550 KQLDYDLFAPMLSRRWRRH-----KEEQDQTAQDETLTKL 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	178/564 (32%)
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	178/562 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448276
Domainoid	1	1.000	74	1.000	Domainoid score	I2508
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900