DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42235 and Slc5a12

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_001102058.1	Gene:	Slc5a12 / 362188	RGDID:	1311652	Length:	619	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	194/588 - (32%)
Similarity:	322/588 - (54%)	Gaps:	42/588 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 ALQHFGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGG 162
            |::.|...||:||.|:..:.:.||.:|                     .::||:.:.:.::||||
  Rat     2 AVKSFEAWDYVVFAALFVISSGIGVFF---------------------AIKERKKTTSREFLVGG 45

  Fly   163 RQMKVFPVALSLVASFVSGISLLGTSTEIYVYGTQYAFILVTLAISGAISWYIFLPVFCNLQLTS 227
            |||...||||||.|||:|.:::|||..|:|.:|..:...|::.|.....:..:|||||....:||
  Rat    46 RQMSFAPVALSLTASFMSAVTVLGTPAEVYRFGASFLIFLISYAFVVFFTSELFLPVFYRSGITS 110

  Fly   228 TYEYFERRFDRRVRIFGSCLFVVMNILWQPICIYVPALTLNQVSGISVSKIVPVTSFICILYTSV 292
            ||||.:.||::.||...:.::::..||:..:.:|.|||.||||:|.::...|..|..:|..|.|:
  Rat   111 TYEYLQLRFNKPVRYAATIIYILQTILYTGVVVYAPALALNQVTGFNLWASVFATGIVCTFYCSL 175

  Fly   293 GGIKGVVWTDVIQGTVMIGSMLIVIIKGTLDLGGLSVVLDHNRQYDRLVGPDMTFDPTARMGVFA 357
            ||:|.|||||..|..|||...|.|:|:|:..:||...||:..|...||...|...||..|...:.
  Rat   176 GGLKAVVWTDAFQMVVMIVGFLTVLIQGSNHVGGFDNVLEQARNGSRLDIVDFDVDPLRRHTFWT 240

  Fly   358 LFVGGALFKLQANGINQAIVQRYLTLPNNKDVKKALVLSLIGFMFVMLMCVYIGLLAFAEFYHCD 422
            :.|||....|...|:||:.:||.::....|..|.||..:|:|...:::..|:.||:.:|.:..||
  Rat   241 IAVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIIVVCAVFCGLIMYAYYKDCD 305

  Fly   423 PITTGLARAKDQVIPLYVVKNVGHIPGLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVE---P 484
            |.|:|...|.||::|.:|::....:|||.|||||..||..||:::.::|:|:.|...|||:   |
  Rat   306 PWTSGAILAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFP 370

  Fly   485 FRKKPLTERQTAYLLRGVVISFGLISMASVPIVQRLGLVMQLSSTVAAITCGPLLGAFSVGMLLP 549
            .    |::..:.::.:|:.:.||:|..:...:...:|.|:|.:.::..:..||:||.|::|::.|
  Rat   371 H----LSDTLSTWISKGLCLLFGIICTSMAVLASLMGSVVQAALSIHGMCGGPMLGLFTLGLVFP 431

  Fly   550 FVKTESLLTGISCASSFTAYIVVRAQIAIFTGSLTFPAKPVSIQDCDYTFDLPANWNATTTATPT 614
            ||..:..|.|:....:.:.::.:.|.:.....|.|.|. |:|.:.|       ...|.|||....
  Rat   432 FVNWKGALGGLLTGITLSFWVGIGAFVYPAPDSKTLPL-PLSTEFC-------VQQNKTTTEAYQ 488

  Fly   615 ESTSHGI----HEISFLWYTAVGSVGTVLGSLLATLYFGRQDPRVVDKELISPV--LRKFWYGKY 673
            .|:...:    :.:|:|:::|||.:|.:...::.:...|||..:.||..||.||  |..||..||
  Rat   489 LSSRPVLADTWYSLSYLYFSAVGCLGCIAAGIIISFLTGRQRGKDVDPLLIRPVCNLFCFWSKKY 553

  Fly   674 ESV 676
            :::
  Rat   554 KTL 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	178/547 (33%)
Slc5a12	NP_001102058.1	SLC5sbd_SMCT2	3..527	CDD:212089	179/556 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340298
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850