DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42235 and CG31668

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_001097055.2	Gene:	CG31668 / 33395	FlyBaseID:	FBgn0051668	Length:	590	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	200/568 - (35%)
Similarity:	324/568 - (57%)	Gaps:	7/568 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 FGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEAL-DYLVGGRQM 165
            ||.|||.||:.:..:...||.|||||.|.:...|.............:..||:.: ||::|.|.:
  Fly     6 FGTVDYAVFLGVTILSIAIGLYFGFIRKSRNGPKTTTPTNEAPERRHQNFGSKKMNDYMMGSRNL 70

  Fly   166 KVFPVALSLVASFVSGISLLGTSTEIYVYGTQYAFILVTLAISGAISWYIFLPVFCNLQLTSTYE 230
            :||||.:||:||.:|.::::||.:|||.|||||.||::.|.:.|....||:||||..||:||:||
  Fly    71 RVFPVGMSLIASCISAVAIIGTPSEIYNYGTQYCFIVIALVLQGLAVSYIYLPVFSALQVTSSYE 135

  Fly   231 YFERRFDRRVRIFGSCLFVVMNILWQPICIYVPALTLNQVSGISVSKIVPVTSFICILYTSVGGI 295
            |.|.||...:|...|.:|::..:|:.|...|:|||.||||||:::..|......||::||.:||:
  Fly   136 YLEMRFHSAIRSIVSIIFILDVVLYLPFLAYLPALALNQVSGMNMYLIEAFIIVICVIYTVLGGL 200

  Fly   296 KGVVWTDVIQGTVMIGSMLIVIIKGTLDLGGLSVVLDHNRQYDRLVGPDMTFDPTARMGVFALFV 360
            |.||.||:.|..:|..|:|.:::..|..:...:..|:...:..||:..:....|.||..|:::.:
  Fly   201 KAVVHTDIWQVVIMFASVLTIVVLATCYIDDQADFLEGLVRGGRLIFSETNPSPFARHTVWSVVI 265

  Fly   361 GGALFKLQANGINQAIVQRYLTLPNNKDVKKALVLSLIGFMFVMLMCVYIGLLAFAEFYHCDPIT 425
            |...:....|.::|.:|.||::||..|..:.::...::|..|.:.:..|:|||.|..:..|||::
  Fly   266 GNTFYWTSLNAVHQTVVHRYMSLPTLKMARASIAFLVVGAAFFISLLCYLGLLIFHAYRDCDPLS 330

  Fly   426 TGLARAKDQVIPLYVVKNVGHIPGLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEPFRKKPL 490
            .||....||::||:||.::||:.|:.|||:||:|.|:|||||..|||.|.|||.|.|....|..|
  Fly   331 AGLIMNDDQLVPLFVVNSLGHVYGMPGLFIAGIFGASLSSLSVYLNSTSLVILQDLVRGCFKMEL 395

  Fly   491 TERQTAYLLRGVVISFGLISMASVPIVQRLGLVMQLSSTVAAITCGPLLGAFSVGMLLPFVKTES 555
            .|..:..:::|.::..||::.|.|.:::::..|:.:|.::|||......|.|:||||:|:..|..
  Fly   396 GEWASTIVVKGSIVVLGLLAFAMVFVLEKVSGVLSISVSLAAIAASSTFGIFTVGMLVPWANTVG 460

  Fly   556 LLTGISCASSFTAYIVVRAQIAIFTGSLTFPAKPVSIQDCDYTFDLPANWNATTTATPTESTSHG 620
            ...|...:...|.:|...:|.|..:|.|.....|||::.|      .||.:....|...|.....
  Fly   461 TAVGGIASVLLTGWISFGSQFAAASGQLGSQRLPVSVEGC------LANASVAENAWVAEEEVFP 519

  Fly   621 IHEISFLWYTAVGSVGTVLGSLLATLYFGRQDPRVVDKELISPVLRKF 668
            ::.:|:.|.:.:|.:..|:...|.:|.....|.:.:|.:||:||:.:|
  Fly   520 LYRLSYHWISPIGVLTVVVVGSLVSLVTKPTDIKSLDSDLITPVIHRF 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	190/541 (35%)
CG31668	NP_001097055.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	187/527 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448251
Domainoid	1	1.000	74	1.000	Domainoid score	I2508
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D32058at33392
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900