DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42235 and Slc5a2

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_573517.1	Gene:	Slc5a2 / 246787	MGIID:	2181411	Length:	670	Species:	Mus musculus

Alignment Length:	531	Identity:	119/531 - (22%)
Similarity:	221/531 - (41%)	Gaps:	93/531 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 QSASPSLEDGEEKLSVKDLSQALQHFGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDG 141
            |......|.||:|:.:.:.:         |.||..|...:...:|.:..|...:       |..|
Mouse     3 QHVEAGSELGEQKVLIDNPA---------DILVIAAYFLLVIGVGLWSMFRTNR-------GTVG 51

  Fly   142 GGAAGVEERRGSEALDYLVGGRQMKVFPVALSLVASFVS-----GISLLGTSTEIYVYGTQYAFI 201
            |               |.:.||.|..:||..||.||.:.     |::..|.::.:.|.|.::..:
Mouse    52 G---------------YFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNAL 101

  Fly   202 LVTLAISGAISWYIFLPVFCNLQLTSTYEYFERRF-DRRVRIFGSCLFVVMNILWQ-PICIYVPA 264
            .|.|.:.     ::|:||:....:.:..:|..:|| ..|:|::.|.|.:.:.|..: .:.::..|
Mouse   102 FVVLLLG-----WLFVPVYLTAGVITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGA 161

  Fly   265 LTLNQVSGISVSKIVPVTSFICILYTSVGGIKGVVWTDVIQGTVMIGSMLIVIIKGTLDLGGLSV 329
            :.:.|..|.::...|.....|.::||..||:..:::||.:|..|::....|:......::||.|.
Mouse   162 VFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSG 226

  Fly   330 VLDHNRQY-----------DRLVG----------PD---MTFDP-TARMGVFALFVGGALFKLQA 369
            :.|   :|           |..||          ||   :..|| |..:...||.:|..:.....
Mouse   227 LFD---KYLGAMTSLTVSKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWY 288

  Fly   370 NGINQAIVQRYLTLPNNKDVKKALVLSLIGF-----MFVMLMCVYIGLLAFAEFYHCDPITTGLA 429
            ...:|.||||.|...|...:|...:  |.|:     ||:|:|...|..:.:.:...|  :...:.
Mouse   289 WCSDQVIVQRCLAGKNLTHIKAGCI--LCGYLKLMPMFLMVMPGMISRILYPDEVAC--VVPEVC 349

  Fly   430 R--------AKDQVIPLYVVKNVGHIPGLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEPFR 486
            :        ..:...|..|||.:.:  ||.||.:|.:.:|.:|||::..||.|.:...|.....|
Mouse   350 KRVCGTEVGCSNIAYPRLVVKLMPN--GLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLR 412

  Fly   487 KKPLTERQTAYLLRGVVISFGLISMASVPIVQRL--GLVMQLSSTVAAITCGPLLGAFSVGMLLP 549
            .: ..:::...:.|..|:....:|:|.:|:||..  |.:.....:|::....|:...|.:.:.:|
Mouse   413 PR-AGDKELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVP 476

  Fly   550 FVKTESLLTGI 560
            .|..:....|:
Mouse   477 RVNEKGAFWGL 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	114/503 (23%)
Slc5a2	NP_573517.1	SLC5-6-like_sbd	22..670	CDD:294310	114/512 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836573
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740