Protein Alignment kumpel and Slc5a11

DIOPT Version :10

• Sequence 1: NP_651446.2
• Gene: kumpel / 43136
• FlyBaseID: FBgn0250757
• Length: 698
• Species: Drosophila melanogaster
• Sequence 2: NP_666310.1
• Gene: Slc5a11 / 233836
• MGIID: 1919316
• Length: 673
• Species: Mus musculus
• Alignment Length: 672
• Identity: 152/672 - (22%)
• Similarity: 274/672 - (40%)
• Gaps: 145/672 - (21%)

  Fly    70 TPTPTPTQSASPSLEDGEEKLSVKDLSQALQHFGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQ 134
            |.:|.|.|  |.|||...:| |::....|:    :|.|.:|:..:.:.:.:         :.|:.
Mouse     5 TISPQPPQ--SDSLEAFPQK-SMEPADIAV----LVLYFLFVLAVGLWSTV---------RTKRD 53

  Fly   135 KLAGKDGGGAAGVEERRGSEALDYLVGGRQMKVFPVALSLVASFV-SG--ISLLGTSTEIYV--- 193
            .:.|                   |.:.|..|..:||..||.||.| ||  |.|.|:...:.:
Mouse    54 TVKG-------------------YFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGAAVGISVA 99

  Fly   194 -YGTQYAFILVTLAISGAISWYIFLPVFCNLQLTSTYEYFERRF-DRRVRIFGSCLFVVMNILWQ 256
             |.....|.::.||       ::|||::...|:|:..||..||| ..|:.|..:.|::.:.|..:
Mouse   100 AYELNGLFSVLMLA-------WVFLPIYIAGQVTTMPEYLRRRFGGNRISITLAVLYLFIYIFTK 157

  Fly   257 -PICIYVPALTLNQVSGISVSKIVPVTSFICILYTSVGGIKGVVWTDVIQGTVMIGSMLIVIIKG 320
             .:.:|..|:.:.|...:.:...:.....|..|||..||:..|::||.:|..:|:....|::...
Mouse   158 ISVDMYAGAIFIQQSLHLDLYLAIVGLLAITALYTVAGGLAAVIYTDALQTVIMLIGAFILMGYS 222

  Fly   321 TLDLGGLS-------VVLDHNRQYDRLVGPDMTFDPTARMGVFALFVG---------GALFKLQA 369
            ...:||:.       :.|..||..:...|       ..|...|.:|..         |.||.:..
Mouse   223 FAAVGGMEGLKDQYFLALASNRSENSSCG-------LPREDAFHIFRDPLTSDLPWPGILFGMSI 280

  Fly   370 NGI-----NQAIVQRYLTLPNNKDVK---------KALVLSLIGFMFVMLMCVYIGLLAFAEFYH 420
            ..:     :|.||||.|...|....|         |.|.|.|:.|..::...::...:|.|....
Mouse   281 PSLWYWCTDQVIVQRSLAAKNLSHAKGGSLMAAYLKVLPLFLMVFPGMVSRVLFPDQVACAHPDI 345

  Fly   421 CDPITTGLARAKDQVIPLYVVKNVGHIP-GLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEP 484
            |..:.:..:...|...|..|::   .:| ||.||.:|.:.:|.:|||::..||.|.:...|....
Mouse   346 CQRVCSNPSGCSDIAYPKLVLE---LLPTGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWNH 407

  Fly   485 FRKKPLTERQTAYLLRGVVISFGLISMASVPIVQ-----RLGLVMQLSSTVAAITCGPLLGAFSV 544
            .|.: .:||:...:.|..|.:..|:|:..:||||     :|.:.:|   ::::....|:...|.:
Mouse   408 IRPR-ASERELMIVGRIFVFALVLVSILWIPIVQASQGGQLFIYIQ---SISSYLQPPVAMVFIM 468

  Fly   545 GMLLPFVKTESLLTGISCASSFTAYIVVRAQIAIFTGSLTFP-AKPVSIQDCDYTFDLPANWNAT 608
            |........:...:|          :::...:.:....|.|. |:|    .||...|.||
Mouse   469 GCFWKRTNEKGAFSG----------LILGLLLGLVRLILDFVYAQP----RCDQPDDRPA----- 514

  Fly   609 TTATPTESTSHGIHEISFLWYTAVGSVGTVLGSLLATLYFGRQDPRVVDKELISPVLRKFWYGKY 673
                       .:.::.:|:::.:.|..|::  .:.|:.:..:.|   .||::|   |..|:.::
Mouse   515 -----------VVKDVHYLYFSMILSFTTLI--TVVTVSWFTETP---SKEMVS---RLTWFTRH 560

  Fly   674 ESVASEEKNNFNLHESETQLKL 695
            |.||.::.     ...||.|.|
Mouse   561 EPVAQKDS-----APPETPLSL 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kumpel	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	127/586 (22%)
Slc5a11	NP_666310.1	SLC5-6-like_sbd	28..673	CDD:444915	142/646 (22%)