DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42235 and Slc5a9

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_663526.3	Gene:	Slc5a9 / 230612	MGIID:	2140201	Length:	685	Species:	Mus musculus

Alignment Length:	568	Identity:	130/568 - (22%)
Similarity:	238/568 - (41%)	Gaps:	96/568 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 SLEDGEEKLSVKDLSQALQHFGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAG 146
            ::|.|..:..|:..:......|:..|.:.:.::        ||.|:        ||   .|..:.
Mouse     7 AMEPGVSRNGVRTETTTNPSLGLHTYDIVVVVI--------YFVFV--------LA---VGIWSS 52

  Fly   147 VEERRGSEALDYLVGGRQMKVFPVALSLVASFV-SG--ISLLGTSTE--IYVYGTQY--AFILVT 204
            :...||:.. .|.:.||.|..:|:..||::|.| ||  |.|.||...  :.|.|.::  .|:|:
Mouse    53 IRASRGTVG-GYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNATFLLL- 115

  Fly   205 LAISGAISWYIFLPVFCNLQLTSTYEYFERRF-DRRVRIFGSCLFVVMNILWQ-PICIYVPALTL 267
                 |:.| ||:||:....:.:..:|.::|| .:|::::.|.|.:::.|..: ...|:..||.:
Mouse   116 -----ALGW-IFVPVYIAAGVVTMPQYLKKRFGGQRIQVYMSVLSLILYIFTKISTDIFSGALFI 174

  Fly   268 NQVSGISVSKIVPVTSFICILYTSVGGIKGVVWTDVIQGTVMIGSMLIVIIKGTLDLG---GLSV 329
            ....|.::.....:...:..:||..||:..|::||.:|..:|:|..|:::..|..::|   ||
Mouse   175 QMALGWNLYLSTVILLVVTAVYTIAGGLTAVIYTDALQTVIMVGGALVLMFLGFQEVGWYPGL-- 237

  Fly   330 VLDHNRQYDRLVGPDMTFDPTA----RMGVFALFVG---------GALFKLQANG-----INQAI 376
                 :|..|...|:.|...|.    |...|.:...         |.:|.|....     .:|.|
Mouse   238 -----QQLYRQAIPNTTVPNTTCHLPRPDAFHMLRDPVNGDIPWPGLIFGLTVLATWCWCTDQVI 297

  Fly   377 VQRYLTLPNNKDVKKALVLSLIGFMFV--MLMCVYIGLLAFAEFYH---------CDPITTGLAR 430
            |||.|...|....|...||.  |::.:  |...|..|:::.|.:..         |..:......
Mouse   298 VQRSLAAKNLSHAKGGSVLG--GYLKILPMFFIVMPGMISRALYPDEVACVDPDICQRVCGARVG 360

  Fly   431 AKDQVIPLYVVKNVGHIP-GLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEPFRKKPLTERQ 494
            ..:...|..|   :..:| ||.||.:|.:.:|.:|||::..||.|.:...|..:.||:: .:|::
Mouse   361 CSNIAYPKLV---MALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFAIDVWQRFRRQ-ASEQE 421

  Fly   495 TAYLLRGVVISFGLISMASVPIVQ--RLGLVMQLSSTVAAITCGPLLGAFSVGMLLPFVKTESLL 557
            ...:.|..|:...:||:..:||:|  ..|.:.....::.:....|:...|.:.:....|......
Mouse   422 LMVVGRLFVVFLVVISILWIPIIQSSNSGQLFDYIQSITSYLAPPITALFLLAIFCKRVNEPGAF 486

  Fly   558 TGISCASSFTAYIVVRAQIAIFTGSLTFPA------KPVSIQDCDYTF 599
            .|:...      :||.....|...|.:.||      :|..::|..|.:
Mouse   487 WGLMFG------LVVGILRMILEFSYSAPACGEMDRRPAVLKDFHYLY 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	126/545 (23%)
Slc5a9	NP_663526.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		3/12 (25%)
		SLC5-6-like_sbd	45..685	CDD:382020	122/514 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..616
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836517
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740