Protein Alignment kumpel and SLC5A9

DIOPT Version :10

• Sequence 1: NP_651446.2
• Gene: kumpel / 43136
• FlyBaseID: FBgn0250757
• Length: 698
• Species: Drosophila melanogaster
• Sequence 2: XP_047304539.1
• Gene: SLC5A9 / 200010
• HGNCID: 22146
• Length: 745
• Species: Homo sapiens
• Alignment Length: 681
• Identity: 140/681 - (20%)
• Similarity: 248/681 - (36%)
• Gaps: 194/681 - (28%)

  Fly    76 TQSASPSLEDGEEKLSVKDLSQALQHFGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKD 140
            |::|.....|....|...|:|.      :|.|.||:..:.:.:.|....|.|
Human    19 TETAPHIALDSRVGLHAYDISV------VVIYFVFVIAVGIWSSIRASRGTI------------- 64

  Fly   141 GGGAAGVEERRGSEALDYLVGGRQMKVFPVALSLVASFV-SG--ISLLGTST------------- 189
             ||              |.:.||.|..:|:..||::|.| ||  |.|.||..
Human    65 -GG--------------YFLAGRSMSWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNM 114

  Fly   190 ----------------------------------------------EIYVYG---------TQYA 199
                                                          .:|:..         :|..
Human   115 RKSRSGGDRGIHPRSHGRTGVRSQVSYFSVRGPPTAQHCLWVGSRPSVYIQDLDTFFFSPLSQAT 179

  Fly   200 FILVTLAISGAISWYIFLPVFCNLQLTSTYEYFERRF-DRRVRIFGSCLFVVMNILWQ-PICIYV 262
            ::|:      |:.| :|:||:....:.:..:|.::|| .:|::::.|.|.:::.|..: ...|:.
Human   180 WLLL------ALGW-VFVPVYIAAGVVTMPQYLKKRFGGQRIQVYMSVLSLILYIFTKISTDIFS 237

  Fly   263 PALTLNQVSGISVSKIVPVTSFICILYTSVGGIKGVVWTDVIQGTVMIGSMLIVIIKGTLDLG-- 325
            .||.:....|.::.....:...:..:||..||:..|::||.:|..:|:|..|:::..|..|:|
Human   238 GALFIQMALGWNLYLSTGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWY 302

  Fly   326 -GLSVVLDHNRQYDRLVGPDMTFDPTA----RMGVFALFVG---------GALFKLQANG----- 371
             ||      .::|.:.: |::|...|.    |...|.:...         |.:|.|....
Human   303 PGL------EQRYRQAI-PNVTVPNTTCHLPRPDAFHILRDPVSGDIPWPGLIFGLTVLATWCWC 360

  Fly   372 INQAIVQRYLTLPNNKDVKKALVLSLIGFMFV--MLMCVYIGLLAFAEFYH---------CDPIT 425
            .:|.||||.|:..:....|...||.  |::.:  |...|..|:::.|.|..         |..|.
Human   361 TDQVIVQRSLSAKSLSHAKGGSVLG--GYLKILPMFFIVMPGMISRALFPDEVGCVDPDVCQRIC 423

  Fly   426 TGLARAKDQVIPLYVVKNVGHIP-GLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEPFRKKP 489
            .......:...|..|   :..:| ||.||.:|.:.:|.:|||::..||.|.:...|..:.||:|.
Human   424 GARVGCSNIAYPKLV---MALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKS 485

  Fly   490 LTERQTAYLLRGVVISFGLISMASVPIVQ--RLGLVMQLSSTVAAITCGPLLGAFSVGMLLPFVK 552
             ||::...:.|..|:...:||:..:||:|  ..|.:......|.:....|:...|.:.:....|.
Human   486 -TEQELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVT 549

  Fly   553 TESLLTGISCASSFTAYIVVRAQIAIFTGSLTFPA--------KPVSIQD----------CDYTF 599
            ......|:    .|...:.:...|..|    ::||        :|..::|          |..|.
Human   550 EPGAFWGL----VFGLGVGLLRMILEF----SYPAPACGEVDRRPAVLKDFHYLYFAILLCGLTA 606

  Fly   600 DLPANWNATTTATPTESTSHGIHEISFLWYT 630
            .:....:..||..|.|..:.      ..|:|
Human   607 IVIVIVSLCTTPIPEEQLTR------LTWWT 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kumpel	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	134/652 (21%)
SLC5A9	XP_047304539.1	SLC5sbd_SGLT4	37..745	CDD:271380	136/663 (21%)