Protein Alignment CG42235 and SLC5A12

DIOPT Version :9

• Sequence 1: NP_651446.2
• Gene: CG42235 / 43136
• FlyBaseID: FBgn0250757
• Length: 698
• Species: Drosophila melanogaster
• Sequence 2: NP_848593.2
• Gene: SLC5A12 / 159963
• HGNCID: 28750
• Length: 618
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 200/607 - (32%)
• Similarity: 330/607 - (54%)
• Gaps: 61/607 - (10%)

  Fly    99 LQHFGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGGR 163
            :::|.:.||:||.|:..:.:.||.:|                     .::||:.:.:.::|||||
Human     3 VKNFAVWDYVVFAALFFISSGIGVFF---------------------AIKERKKATSREFLVGGR 46

  Fly   164 QMKVFPVALSLVASFVSGISLLGTSTEIYVYGTQY-----AFILVTLAISGAISWYIFLPVFCNL 223
            ||...||.|||.|||:|.:::|||.:|:|.:|..:     |::.|.|..|     .:|||||...
Human    47 QMSFGPVGLSLTASFMSAVTVLGTPSEVYRFGASFLVFFIAYLFVILLTS-----ELFLPVFYRS 106

  Fly   224 QLTSTYEYFERRFDRRVRIFGSCLFVVMNILWQPICIYVPALTLNQVSGISVSKIVPVTSFICIL 288
            .:||||||.:.||::.||...:.:::|..||:..:.:|.|||.||||:|..:...|..|..:|..
Human   107 GITSTYEYLQLRFNKPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTF 171

  Fly   289 YTSVGGIKGVVWTDVIQGTVMIGSMLIVIIKGTLDLGGLSVVLDHNRQYDRLVGPDMTFDPTARM 353
            |.::||:|.|||||..|..|||...|.|:|:|:...||...||:.:....||...|...||..|.
Human   172 YCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRH 236

  Fly   354 GVFALFVGGALFKLQANGINQAIVQRYLTLPNNKDVKKALVLSLIGFMFVMLMCVYIGLLAFAEF 418
            ..:.:.|||....|...|:||:.:||.::....|..|.||..:|:|...:::..|:.||:.::.|
Human   237 TFWTITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHF 301

  Fly   419 YHCDPITTGLARAKDQVIPLYVVKNVGHIPGLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVE 483
            ..|||.|:|:..|.||::|.:|::....:|||.|||||..||..||::::::|:|:.|...|||:
Human   302 KDCDPWTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVK 366

  Fly   484 ---PFRKKPLTERQTAYLLRGVVISFGLISMASVPIVQRLGLVMQLSSTVAAITCGPLLGAFSVG 545
               |.    |:::.:.::.:|:.:.||::..:.......:|.|:|.|.::..:..||:||.||:|
Human   367 SCFPH----LSDKLSTWISKGLCLLFGVMCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLG 427

  Fly   546 MLLPFVKTESLLTGISCASSFTAYIVVRAQIAIFTGSLTFPAKPVSIQDCDYTFDLPANWNATTT 610
            ::.|||..:..|.|:....:.:.::.:.|.|.....|.|:|. |:|...|       ...|.|.|
Human   428 IVFPFVNWKGALGGLLTGITLSFWVAIGAFIYPAPASKTWPL-PLSTDQC-------IKSNVTAT 484

  Fly   611 ATPTESTSHGI----HEISFLWYTAVGSVGTVLGSLLATLYFGRQDPRVVDKELISPV--LRKFW 669
            ..|..|:..||    :.||:|:|:|||.:|.::..::.:|..|||....:...||.||  |..||
Human   485 GPPVLSSRPGIADTWYSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPLLIRPVCNLFCFW 549

  Fly   670 YGKYESV---------ASEEKN 682
            ..||:::         .:|::|
Human   550 SKKYKTLCWCGVQHDSGTEQEN 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	184/552 (33%)
SLC5A12	NP_848593.2	SLC5sbd_SMCT2	3..527	CDD:212089	186/561 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146501
Domainoid	1	1.000	49	1.000	Domainoid score	I11782
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.850