DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42235 and Slc5a5

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_444478.2	Gene:	Slc5a5 / 114479	MGIID:	2149330	Length:	618	Species:	Mus musculus

Alignment Length:	585	Identity:	194/585 - (33%)
Similarity:	300/585 - (51%)	Gaps:	50/585 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 FGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGGRQMK 166
            ||..||.||..||.|...||.:.|.....|:                     .|.|:..||||:.
Mouse    12 FGPWDYGVFATMLLVSTGIGLWVGLARGGQR---------------------SADDFFTGGRQLA 55

  Fly   167 VFPVALSLVASFVSGISLLGTSTEIYVYGTQYAFILVTLAISGAISWYIFLPVFCNLQLTSTYEY 231
            ..||.|||.|||:|.:.:||...|...||.::.::.|...::..::..:|||:|..|.|||||:|
Mouse    56 AVPVGLSLAASFMSAVQVLGVPAEAARYGLKFLWMCVGQLLNSLLTALLFLPIFYRLGLTSTYQY 120

  Fly   232 FERRFDRRVRIFGSCLFVVMNILWQPICIYVPALTLNQVSGISVSKIVPVTSFICILYTSVGGIK 296
            .|.||.|.||:.|:..::|..:|:..|.||.|||.||||:|:.:...:..|..||.|||:|||:|
Mouse   121 LELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMK 185

  Fly   297 GVVWTDVIQGTVMIGSMLIVIIKGTLDLGGLSVVLDHNRQYDRLVGPDMTFDPTARMGVFALFVG 361
            .||||||.|..||:....:::.:|.:.:||...||...:.:.|:...|...||.:|...:...||
Mouse   186 AVVWTDVFQVVVMLVGFWVILARGVMLMGGPWNVLSLAQNHSRINLMDFDPDPRSRYTFWTFVVG 250

  Fly   362 GALFKLQANGINQAIVQRYLTLPNNKDVKKALVLSLIGFMFVMLMCVYIGLLAFAEFYHCDPITT 426
            |:|..|...|:|||.||||:.....:..|.||:::.:|...::......|::.|..:..|||:.|
Mouse   251 GSLVWLSMYGVNQAQVQRYVACHTERKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLT 315

  Fly   427 GLARAKDQVIPLYVVKNVGHIPGLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEPFRKKPLT 491
            |...|.||.:||.|:.....:||:.|||:|..:|..||:.||::|:::.|.:.|.::| |...|.
Mouse   316 GRIAAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKP-RMPSLA 379

  Fly   492 ERQTAYLLRGVVISFGLISMASVPIVQRL-GLVMQLSSTVAAITCGPLLGAFSVGMLLPFVKTES 555
            .|:..::.:|:...:|...:....:...| |.|:|.|.||..:..|||||||::|||||...|..
Mouse   380 PRKLVFISKGLSFIYGSTCLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPG 444

  Fly   556 LLTGISCASSFTAYIVVRAQIAIFTGSLTFPAKPVSIQDCDYTFDLPANWNATTTA--TPTESTS 618
            :|:|::...:.:.::.|.|.: ...|..|....|.|...|.....||:...|..|:  .|:....
Mouse   445 VLSGLTAGLAVSLWVAVGATL-YPPGEQTMGVLPTSAAGCTNASVLPSPPGAANTSRGIPSSGMD 508

  Fly   619 HG-------IHEISFLWYTAVGSVGTVL-GSLLATLY----------------FGRQDPRVVDKE 659
            .|       .:.:|:|:|.|:|::.|:| |:|::.|.                ..||...|..||
Mouse   509 SGRPAFADTFYAVSYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQTASVAPKE 573

Fly 660 659
Mouse 574 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	186/551 (34%)
Slc5a5	NP_444478.2	SLC5sbd_NIS	15..549	CDD:271393	187/556 (34%)
Slc5a5	NP_444478.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	571..618		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836569
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850