DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42235 and slc5a7a

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	XP_021332411.1	Gene:	slc5a7a / 100005589	ZFINID:	ZDB-GENE-090313-273	Length:	592	Species:	Danio rerio

Alignment Length:	584	Identity:	115/584 - (19%)
Similarity:	233/584 - (39%)	Gaps:	121/584 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 GIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGGRQMKV 167
            |:|..::|..::   .::|.:..:          ..|:.|...|.:.   ||.:  :||||.:.:
Zfish     7 GLVAIVIFYLLI---LLVGIWAAW----------KNKNSGVMEGTDR---SETI--MVGGRDIGL 53

  Fly   168 FPVALSLVASFVSGISLLGTSTEIYV--YGTQYAFILVTLAISGAISWYIFLPVFCNLQLTSTYE 230
            |..|.::.|::|.|..:.||:..:|:  :|..:|......|:|..:....|.....:....:..:
Zfish    54 FVGAFTMTATWVGGGYINGTAEYVYLPGFGLAWAQAPFGYALSLVLGGLFFAKPMRSRGYVTMLD 118

  Fly   231 YFERRFDRRVRIFGSCLFV---VMNILWQPICIYVPALTLNQVSGISVSKIVPVTSFICILYTSV 292
            .|::.:.:|:   |..||:   :..:.|....:.....||:.:..|.::..|.:::.|.|.||.|
Zfish   119 PFQQLYGKRM---GGLLFIPALMGEMFWSAAILSALGATLSVIIDIDINMSVVISALIAIFYTLV 180

  Fly   293 GGIKGVVWTDVIQ-GTVMIGSMLIVIIKGTL------DLGGLSVVLDHNRQYDRLVGPDMTFDPT 350
            ||:..|.:|||:| ..:.:|  |.|.:...|      |:|..:|...|..|             |
Zfish   181 GGLYSVAYTDVVQLFCIFLG--LWVSVPFALSNPAVSDIGVTAVKQLHANQ-------------T 230

  Fly   351 ARMGVF-------------ALFVGGALFKLQANGINQAIVQRYLTLPNNKDVKKALVLSLIGFMF 402
            |.:|..             .|.:||..:        |...||.|:..:....:....|:..|.:.
Zfish   231 AWLGKIESSDKWMWADNFCLLMLGGIPW--------QVYFQRVLSASSATYAQVLSFLAAFGCII 287

  Fly   403 VMLMCVYIGLLAFAEFYH---CDPITTGLARAKDQVIPLYVVKNVGHIPGLVGLFVAGVFSAA-L 463
            :.:..|.||.:..:..::   ..||........|.::|: |::::  .|..:..|..|..||| :
Zfish   288 MAIPSVLIGAIGASTDWNQTSYGPIPPMQKDQSDMILPI-VLQHL--CPAYISFFGLGAVSAAVM 349

  Fly   464 SSLSTALNSLSGVILTDFVEPFRKKPLTERQTAYLLRGVVISFGLISMASVPIVQRLGLVMQLSS 528
            ||..:::.|.|.:...:..:...::..::|:..:::|..:..||.::.|...:...:..:..|||
Zfish   350 SSADSSILSASSMFARNIYQLAFRQSASDREIVWVMRITIFVFGALATAMALLTGTVYGLWYLSS 414

  Fly   529 TVAAITCGPLLGAFSVGMLLPFVKTESLLTGISCASSFTAY---IVVRAQIAIFTGSLTFPAKPV 590
            .:..:            ::.|.:.:...:.|.:...|...|   :::|     ..|...:...|.
Zfish   415 DLVYV------------IIFPQLLSVLFIRGTNTYGSVAGYFFGLILR-----IGGGEPYLKLPP 462

  Fly   591 SIQDCDYTFDLPANWNATTTATPTESTSHGIHEISFL------WYTAVGSVGTVLGSLLATLYF 648
            .|....:|.:              |...|..||:.:|      :.||     ::|.|.|:.:.|
Zfish   463 FIYYPGWTIE--------------EKVHHLTHEVEYLVMQRFPFKTA-----SMLASFLSNVAF 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	113/578 (20%)
slc5a7a	XP_021332411.1	SLC5sbd_CHT	8..508	CDD:271368	114/583 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580114
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840