DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42235 and slc5a3a

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_001153309.1	Gene:	slc5a3a / 100004287	ZFINID:	ZDB-GENE-090312-3	Length:	671	Species:	Danio rerio

Alignment Length:	608	Identity:	133/608 - (21%)
Similarity:	241/608 - (39%)	Gaps:	131/608 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 IAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGGRQMKVFPVALSLV 175
            |.::|:..|:...|||....:..:       |..:|           |.:.||.|..|.:..||.
Zfish    10 IIVVAMYFVLVLCFGFFSMWRANR-------GTVSG-----------YFLAGRSMNWFVIGASLF 56

  Fly   176 ASFVS-----GISLLGTSTEIYVYGTQY-AFILVTLAISGAISWYIFLPVFCNLQLTSTYEYFER 234
            .|.:.     |::..|.::.:.|...:: |.:|:.|     :.| :|:||:.:..:.:..||..:
Zfish    57 VSNIGSEHFIGLAGSGAASGLAVGAWEFNAILLLQL-----LGW-VFIPVYIHSGVYTMPEYLSK 115

  Fly   235 RF-DRRVRIFGSCLFVVMNILWQ-PICIYVPALTLNQVSG----ISVSKIVPVTSFICILYTSVG 293
            || ..|::|:.:.|.:::.|..: .:.:|..||.:.:..|    :|:..::.:|:    |.|..|
Zfish   116 RFGGNRLKIYFASLTLLLYIFTKLSVDLYSGALFIQESLGWNLYLSIILLITLTA----LLTVTG 176

  Fly   294 GIKGVVWTDVIQGTVMIGSMLIVIIKGTLDLGGLS---------------VVLDHNRQYDRL--V 341
            |:..|::||.:|..:||...|.::....:.:|||.               :.|::|..|...  |
Zfish   177 GLVAVIYTDTLQAFLMISGALCLMAISLVKVGGLEGLRTKYMNALPNITFITLENNLTYSNSCHV 241

  Fly   342 GP--------------DMTFDPTARMGVFALFVGGALFKLQANGINQAIVQRYLTLPNNKDVKKA 392
            .|              |:.:.        |..:|.....:.....:|.||||.|...|....|.:
Zfish   242 NPKADSFKLLRSPLDKDLPWP--------AFLLGQTPASIWYWCADQVIVQRVLAARNIAHAKGS 298

  Fly   393 LVLSLIGFMFVMLMCVYIGLLA---FAEFY------HCDPITTGLARAKDQVIPLYVVKNVGHIP 448
            .:|:.:..:..|.:.|..|:::   ||:..      ||..:....|...:...| .:|.|:..:
Zfish   299 TLLAGVLKVLPMFIIVIPGMISRVLFADELACIGPEHCMQVCNSRAGCTNTAYP-RLVMNIMPV- 361

  Fly   449 GLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEPFRKKPLTERQTAYLLRGVVISFGLISMAS 513
            ||.||.:|.:.:|.:|.|.:..||.|.:...|..:..|.: .:.::...:.|..|:....||:|.
Zfish   362 GLRGLMMAVMLAALMSDLDSIFNSASTIFTLDIYKMIRHQ-ASSKELMVVGRLFVVLIVAISIAW 425

  Fly   514 VPIVQRL--GLVMQLSSTVAAITCGPLLGAFSVGMLLPFVKTESLLTGISCASSFTAYI--VVRA 574
            ||.|..:  |.:......|:.....|:...|.:|:|...........|     .|...|  :||.
Zfish   426 VPFVIEMQGGQMFLYIQEVSDYLTPPIAALFLLGVLWKRCNETGAFWG-----GFVGLILGIVRL 485

  Fly   575 QIAIFTGSLTFPAKPVSIQDCDYTFDLPANWNATTTATPTESTSHGIHEISFLWYTAVGSVGTVL 639
            .:|...      .:|    |||...|.||                .|.::.|::..||  :..|.
Zfish   486 ILAFVY------REP----DCDSVDDRPA----------------FIKDVHFMYVAAV--LFWVS 522

  Fly   640 GSLLATLYFGRQDPRVVDKELIS 662
            |.::..:......|   .||.||
Zfish   523 GFVMVVVSLCTNPP---SKEQIS 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	128/590 (22%)
slc5a3a	NP_001153309.1	SLC5-6-like_sbd	9..671	CDD:294310	133/608 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580120
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740