DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31089 and LIPN

DIOPT Version :9

Sequence 1:	NP_733128.1	Gene:	CG31089 / 43135	FlyBaseID:	FBgn0051089	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001095939.1	Gene:	LIPN / 643418	HGNCID:	23452	Length:	398	Species:	Homo sapiens

Alignment Length:	411	Identity:	129/411 - (31%)
Similarity:	197/411 - (47%)	Gaps:	22/411 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLVLVALAVGVYSAAIDGPIDFYKLYDNPEAHISLKSKITTADRTAAHGYPSEHHHIVTEDGYIL 72
            ||....|..|..:|.  |.:|..... |||..::      |::....:|||||.:.:.|||||||
Human     5 LLTTTCLICGTLNAG--GFLDLENEV-NPEVWMN------TSEIIIYNGYPSEEYEVTTEDGYIL 60

  Fly    73 GVFRIPYSHKLQNQNEKRPIVLLQHGLTSCSDAWILQGPNDGLPYLLADAGFDVWMGNARGTSYS 137
            .|.||||..........||:|.:||.|.:.:..|:....|..|.:||||||:||||||:||.::|
Human    61 LVNRIPYGRTHARSTGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWMGNSRGNTWS 125

  Fly   138 RNHTTLSPDHPNFWKFSWHEIGIYDITAIIDYALSTENGQGQDAIHYVGHSQGTTVFFALMSWIP 202
            |.|.|||.....||.||:.|:..||:..:||:.:   |..||:.::::|||.|||:.|...|.:|
Human   126 RRHKTLSETDEKFWAFSFDEMAKYDLPGVIDFIV---NKTGQEKLYFIGHSLGTTIGFVAFSTMP 187

  Fly   203 EYNDKIKTAHMFAPVAIMKNLSSGLVRSVGPYLGHRNTYSVLFGSQEFLPHNEFLMAIFFNICQP 267
            |...:||......|....|..:....|.   :|...:....:||::.|...::........||.
Human   188 ELAQRIKMNFALGPTISFKYPTGIFTRF---FLLPNSIIKAVFGTKGFFLEDKKTKIASTKICN- 248

  Fly   268 DFMLRPVCESAMEKLYAGG---RVNMTAMPEGMATHPAGCSTDQMLHYLQEQQSGYFRLFDHGT- 328
            :.:|..:|...| .|:||.   .:|.:.|...|:..|.|.|...:||..|...|..||.:|.|.
Human   249 NKILWLICSEFM-SLWAGSNKKNMNQSRMDVYMSHAPTGSSVHNILHIKQLYHSDEFRAYDWGND 312

  Fly   329 KKNLEVYGTQEPPEYPVELINSLVHMWYADSDNLAAVEDVEQIAERLPNKVMHRMADTEWNHGDF 393
            ..|::.|....||.|.:..:.....:|....|.|...:||.:|..::.:....::. .:|||.||
Human   313 ADNMKHYNQSHPPIYDLTAMKVPTAIWAGGHDVLVTPQDVARILPQIKSLHYFKLL-PDWNHFDF 376

  Fly   394 ALNWEVRKYINEPVIDIMMEY 414
            ....:..:.:...:|.:|..|
Human   377 VWGLDAPQRMYSEIIALMKAY 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31089	NP_733128.1	Abhydro_lipase	48..110	CDD:282003	25/61 (41%)
CG31089	NP_733128.1	Abhydrolase	<86..>237	CDD:304388	57/150 (38%)
LIPN	NP_001095939.1	Abhydro_lipase	36..97	CDD:282003	25/60 (42%)
		Abhydrolase_1	79..379	CDD:278959	97/308 (31%)
		Abhydrolase	106..>175	CDD:304388	35/71 (49%)
		Abhydrolase	<149..>234	CDD:304388	26/90 (29%)
		Abhydrolase_5	<322..374	CDD:289465	11/52 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141751
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.950