DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31089 and LIPA

DIOPT Version :9

Sequence 1:	NP_733128.1	Gene:	CG31089 / 43135	FlyBaseID:	FBgn0051089	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_000226.2	Gene:	LIPA / 3988	HGNCID:	6617	Length:	399	Species:	Homo sapiens

Alignment Length:	424	Identity:	146/424 - (34%)
Similarity:	218/424 - (51%)	Gaps:	39/424 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RFTGSLLVLVALAV-----GVYSAAIDGPIDFYKLYDNPEAHISLKSKITTADRTAAHGYPSEHH 62
            ||.|.::.||...:     |....|:|           ||.::::...|      :..|:|||.:
Human     4 RFLGLVVCLVLWTLHSEGSGGKLTAVD-----------PETNMNVSEII------SYWGFPSEEY 51

  Fly    63 HIVTEDGYILGVFRIPYSHKLQNQNEKRPIVLLQHGLTSCSDAWILQGPNDGLPYLLADAGFDVW 127
            .:.|||||||.:.|||:..|..:....:|:|.|||||.:.|..|:....|..|.::|||||||||
Human    52 LVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVW 116

  Fly   128 MGNARGTSYSRNHTTLSPDHPNFWKFSWHEIGIYDITAIIDYALSTENGQGQDAIHYVGHSQGTT 192
            |||:||.::||.|.|||.....||.||:.|:..||:.|.|::.|   |..||:.::|||||||||
Human   117 MGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFIL---NKTGQEQVYYVGHSQGTT 178

  Fly   193 VFFALMSWIPEYNDKIKTAHMFAPVAIMKNLSSGLVRSVGPYLGHRNTYSV--LFGSQEFLPHNE 255
            :.|...|.|||...:||......|||.:...:|.:.:     ||....:.:  |||.:||||.:.
Human   179 IGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAK-----LGRLPDHLIKDLFGDKEFLPQSA 238

  Fly   256 FLMAIFFNICQPDFMLRPVCESAMEKL--YAGGRVNMTAMPEGMATH-PAGCSTDQMLHYLQEQQ 317
            ||..:..::| ...:|:.:|.:....|  :....:||:.: :...|| |||.|...|||:.|..:
Human   239 FLKWLGTHVC-THVILKELCGNLCFLLCGFNERNLNMSRV-DVYTTHSPAGTSVQNMLHWSQAVK 301

  Fly   318 SGYFRLFDHGTK-KNLEVYGTQEPPEYPVELINSLVHMWYADSDNLAAVEDVEQIAERLPNKVMH 381
            ...|:.||.|:. ||...|....||.|.|:.:.....:|....|.||.|.||..:..::.|.|.|
Human   302 FQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQITNLVFH 366

  Fly   382 RMADTEWNHGDFALNWEVRKYINEPVIDIMMEYE 415
            . :..||.|.||....:....:...:|::|.:|:
Human   367 E-SIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31089	NP_733128.1	Abhydro_lipase	48..110	CDD:282003	24/61 (39%)
CG31089	NP_733128.1	Abhydrolase	<86..>237	CDD:304388	65/150 (43%)
LIPA	NP_000226.2	PLN02872	38..396	CDD:215470	134/374 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141795
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.980