DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31089 and Lipa

DIOPT Version :9

Sequence 1:	NP_733128.1	Gene:	CG31089 / 43135	FlyBaseID:	FBgn0051089	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_036864.3	Gene:	Lipa / 25055	RGDID:	3008	Length:	397	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	141/417 - (33%)
Similarity:	211/417 - (50%)	Gaps:	38/417 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LVALAVGVYSAAIDGPIDFYKLYDNPEAHISLKSKITTADRTAAH-GYPSEHHHIVTEDGYILGV 74
            ::...||:..:.  ||.......| |||::::...|       .| |||.|.|.:.|.|||||||
  Rat     7 VICFVVGILLSG--GPTGTISAVD-PEANMNVTEII-------MHWGYPGEEHSVQTGDGYILGV 61

  Fly    75 FRIPYSHKLQNQNEKRPIVLLQHGLTSCSDAWILQGPNDGLPYLLADAGFDVWMGNARGTSYSRN 139
            .|||:..|.|.....:|:|.||||..:.|..|:....|:.|.::||||||||||||:||.::||.
  Rat    62 HRIPHGRKNQFDKGPKPVVYLQHGFLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRK 126

  Fly   140 HTTLSPDHPNFWKFSWHEIGIYDITAIIDYALSTENGQGQDAIHYVGHSQGTTVFFALMSWIPEY 204
            |.|||.....:|.||:.|:..||:.|.|:|.|   |..||:.::|||||||.|:.|...|.:||.
  Rat   127 HKTLSVSQDEYWAFSFDEMAKYDLPASINYIL---NKTGQEQLYYVGHSQGCTIGFIAFSQMPEL 188

  Fly   205 NDKIKTAHMFAPVAIMKNLSSGLVRSVG--PYLGHRNTYSVLFGSQEFLPHNEFLMAIFFNICQP 267
            ..|:|.....||| :..|.:||.:..:|  |.|    ....|||.::|||.:..:..:..:|| .
  Rat   189 AKKVKMFFALAPV-LSLNFASGPMVKLGRLPDL----LLEDLFGQKQFLPQSAMVKWLSTHIC-T 247

  Fly   268 DFMLRPVCESAM-------EKLYAGGRVNMTAMPEGMATH-PAGCSTDQMLHYLQEQQSGYFRLF 324
            ..:::.:|.:..       ||     .:||:.: :...|| |||.|...|:|:.|..:....:.|
  Rat   248 HVIMKELCANIFFLICGFNEK-----NLNMSRV-DVYTTHCPAGTSVQNMVHWTQVVKYHKLQAF 306

  Fly   325 DHGTK-KNLEVYGTQEPPEYPVELINSLVHMWYADSDNLAAVEDVEQIAERLPNKVMHRMADTEW 388
            |.|:. ||...|....||.|.::.:.....:|....|.||...|:..:...:|..|.|:.. .||
  Rat   307 DWGSSDKNYFHYNQSYPPLYSIKDMQLPTALWSGGKDWLADTSDINILLTEIPTLVYHKNI-PEW 370

  Fly   389 NHGDFALNWEVRKYINEPVIDIMMEYE 415
            :|.||....:....:...|:.:|.:|:
  Rat   371 DHLDFIWGLDAPWRLYNEVVSLMKKYQ 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31089	NP_733128.1	Abhydro_lipase	48..110	CDD:282003	27/62 (44%)
CG31089	NP_733128.1	Abhydrolase	<86..>237	CDD:304388	66/152 (43%)
Lipa	NP_036864.3	PLN02872	7..394	CDD:215470	139/412 (34%)
		Abhydro_lipase	35..96	CDD:282003	28/67 (42%)
		Abhydrolase_5	78..>203	CDD:289465	60/128 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335498
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2916
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.000