DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31089 and Lipk

DIOPT Version :9

Sequence 1:	NP_733128.1	Gene:	CG31089 / 43135	FlyBaseID:	FBgn0051089	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001192278.1	Gene:	Lipk / 240633	MGIID:	2679259	Length:	403	Species:	Mus musculus

Alignment Length:	401	Identity:	136/401 - (33%)
Similarity:	209/401 - (52%)	Gaps:	15/401 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 IDGPIDFYK--LYDNPEAHISLKSKITTADRTAAHGYPSEHHHIVTEDGYILGVFRIPYSHKLQN 85
            :.||||.||  ...||||::::.. :..::..:..|||.|.|.::||||||||.:|||:......
Mouse    13 LSGPIDGYKQESITNPEANMNIVC-VFQSELISYWGYPYEKHDVITEDGYILGTYRIPHGKGCSR 76

  Fly    86 QNEKRPIVLLQHGLTSCSDAWILQGPNDGLPYLLADAGFDVWMGNARGTSYSRNHTTLSPDHPNF 150
            :...:.:|.|||||.:.::.||...||:.|.:||||:|:|||:||:||.::||||..|||..|.:
Mouse    77 KTAPKAVVYLQHGLIASANNWICNLPNNSLAFLLADSGYDVWLGNSRGNTWSRNHLRLSPKSPQY 141

  Fly   151 WKFSWHEIGIYDITAIIDYALSTENGQGQDAIHYVGHSQGTTVFFALMSWIPEYNDKIKTAHMFA 215
            |.|||.|:..||:.|.::..|..   .||..:.|||||||||:.|...|..||...||:.....|
Mouse   142 WAFSWDEMAKYDLPATVNLILEK---SGQKQLFYVGHSQGTTIAFIAFSTNPELAKKIRLFFALA 203

  Fly   216 PVAIMKNLSSGLVRSVGPYLGHRNTYSVLFGSQEFLPHNEFLMAIFFNICQPDFMLRPVCESAME 280
            |||.:|...|.:.:..   ...|....||||.:.|..|..|...|...:|... :...:|.:.:.
Mouse   204 PVATVKYTRSPMKKLT---TLSRKAVKVLFGDKMFSTHTWFEQFIATKVCNRK-LFHQLCSNFLF 264

  Fly   281 KL--YAGGRVNMTAMPEGMATHPAGCSTDQMLHYLQEQQSGYFRLFDHGT-KKNLEVYGTQEPPE 342
            .|  :....:||:.:...::..|||.|...|||:.|...||..:.||.|. .:|:..:....||.
Mouse   265 SLSGFDPQNLNMSRLDVYLSQSPAGTSVQNMLHWAQAVNSGQLQAFDWGNPDQNMMHFNQLTPPV 329

  Fly   343 YPVELINSLVHMWYADSDNLAAVEDVEQIAERLPNKVMHRMADTEWNHGDFALNWEVRKYINEPV 407
            |.:..:.....||....|.:|..:|.:.:..::.|.:.::.. ..:||.||.|..:..:.:...:
Mouse   330 YNISKMRVPTAMWSGGQDVVADAKDTKNLLPKIANLIYYKEI-PHYNHMDFYLGQDAPQEVYGDL 393

  Fly   408 IDIMMEYELKN 418
            |. |:|..|:|
Mouse   394 IR-MIEESLQN 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31089	NP_733128.1	Abhydro_lipase	48..110	CDD:282003	24/61 (39%)
CG31089	NP_733128.1	Abhydrolase	<86..>237	CDD:304388	63/150 (42%)
Lipk	NP_001192278.1	Abhydro_lipase	40..101	CDD:282003	24/60 (40%)
		Abhydrolase_5	82..>210	CDD:289465	61/130 (47%)
		Abhydrolase_1	83..382	CDD:278959	104/306 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831770
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2217
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.930