DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5913 and Fam98a

DIOPT Version :9

Sequence 1:	NP_651439.2	Gene:	CG5913 / 43132	FlyBaseID:	FBgn0039385	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_598508.2	Gene:	Fam98a / 72722	MGIID:	1919972	Length:	515	Species:	Mus musculus

Alignment Length:	492	Identity:	178/492 - (36%)
Similarity:	258/492 - (52%)	Gaps:	62/492 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LELYLVDSLKALSFQGHCQKQENLSRALDAGIESPDMQEVVLWLAHELHILRKTDERVNQGKALN 68
            :|..:::||:.|.::|.......|.:|:.||..||:..::..||..||.:|.|.:|.|   :|.|
Mouse     6 METDILESLEDLGYKGPLLDDGALLQAVSAGAASPEFTKLCAWLVSELRVLCKLEENV---QATN 67

  Fly    69 -----KDFSFELSLLLTELGCPYRELVQGPIEQRFKSRMALVQLLEYLTSELMTTKMVLKAQPVG 128
                 ::|..|:|.||.|:.|||..|..|.:.:|.......:.||.||.|||...:|:.    |.
Mouse    68 SPSEAEEFQLEVSGLLGEMNCPYPSLTSGDVTKRLLVEKNCLLLLTYLISELEAARMLC----VN 128

  Fly   129 PPCKRSKV--DTNVQQVVENLAKDLQLGEVPKNINTKMLFEKITPRLEQAIKKTNPQVLSEPLLK 191
            .|.|:::.  .:.|.|.::.:...|.:.:.|.||.....|..|..:|::.:.|..|..:.:||
Mouse   129 APPKKAQEGGGSEVFQELKGICIALGMSKPPANITMFQFFSGIEKKLKETLAKVPPNHVGKPL-- 191

  Fly   192 LKKPLTDAQWQLLETLHRELEAEYNLRRQMMSTRLEATVQSFQWSESMRQRSNEIMDRFNRKMRE 256
            ||||:..|.|:.:|.:::.:..||.:||:::..||:.|||||.||:..:.:::::...:..| |.
Mouse   192 LKKPMGPAHWEKIEAINQAIANEYEVRRKLLIKRLDVTVQSFGWSDRAKSQTDKLAKVYQPK-RS 255

  Fly   257 LDQFKVGGKQTDLVALLAARSDLAIIEKTSSANVRKNTASKIQKHVIGRVPDRGGRANEHAPPPP 321
            |...|  || ..:..|||||.||:.|.:|||.::|:.||..|.|.::|||||||||.||..||||
Mouse   256 LLSPK--GK-VSVAHLLAARQDLSKILRTSSGSIREKTACAINKVLMGRVPDRGGRPNEIEPPPP 317

  Fly   322 EMPSWQQ-----QRASGPPGGGRGG---------GGNFRGGRGGGGG---GGFGGGRGG------ 363
            |||.||:     |:.:|..||||||         ||:.:|||||.|.   ||.|||||.
Mouse   318 EMPPWQKRQDGPQQQAGGRGGGRGGYEHSSYGGRGGHEQGGRGGRGSYDHGGRGGGRGNKHQGGW 382

  Fly   364 --GGGGGGGNWQQPQQQQQQHQNQSYEQRDRSDRNDQQWISGSGRVQ-----GTGWNPQGG---R 418
              ||.|.||.:|....:....|...|    ....:......|.|..|     |:|:  |||   :
Mouse   383 TDGGSGSGGGYQDGAYRDSGFQPGGY----HGGHSGGYQAGGYGGFQTSSYTGSGY--QGGGYQQ 441

  Fly   419 DGGGRDGG--GRDGGGRDGGGRGRGGGGGRGGYRGGY 453
            |...:|||  |..|.||.|.| ||||.||||...||:
Mouse   442 DNRYQDGGHHGERGSGRGGRG-GRGGRGGRGSQGGGW 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5913	NP_651439.2	DUF2465	9..328	CDD:287241	117/325 (36%)
Fam98a	NP_598508.2	DUF2465	11..327	CDD:287241	118/328 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..410		51/116 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	432..515		24/49 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849905
Domainoid	1	1.000	190	1.000	Domainoid score	I3269
eggNOG	1	0.900	-	-		E1_KOG3973
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41042
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3187
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45991
OrthoDB	1	1.010	-	-		D346789at33208
OrthoFinder	1	1.000	-	-		FOG0002269
OrthoInspector	1	1.000	-	-		oto95422
orthoMCL	1	0.900	-	-		OOG6_100518
Panther	1	1.100	-	-	O	PTHR31353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5346
SonicParanoid	1	1.000	-	-		X2296
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840