DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lnk and sh2b1

DIOPT Version :9

Sequence 1:	NP_001287536.1	Gene:	Lnk / 43130	FlyBaseID:	FBgn0028717	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_001103925.1	Gene:	sh2b1 / 558152	ZFINID:	ZDB-GENE-070209-188	Length:	906	Species:	Danio rerio

Alignment Length:	1074	Identity:	254/1074 - (23%)
Similarity:	344/1074 - (32%)	Gaps:	546/1074 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PTSASSHHSLGTSSAAAAAAAGSDLI-----------PAPIGTGNAMGVSSYAYGGT-------S 67
            |.:|::...|..|.:.:.:.....|:           |.|:|    ..:||.:...|       |
Zfish    11 PRAAANSSPLPPSPSPSPSPPSPSLLPLSTRPPPLPPPTPVG----QPLSSLSDTPTPSPSPCLS 71

  Fly    68 WEEFCERHARVAASDFAKACITYI--NGNLPPEEARNIQHRSFAQKFVESFSAHYDTEF----FK 126
            |.||||.||||||.|||:....::  |.|..|:.|     ..|.::|.:.|..|:::|.    ..
Zfish    72 WTEFCELHARVAAGDFARHFRAFLQENPNYSPDSA-----ALFCRRFTDRFVRHFESELEVTGIS 131

  Fly   127 RRSTL------------------------------------------------------KSG--- 134
            |..|:                                                      .||
Zfish   132 REGTVNWVAQSDVTSLEEDAASPSLLTAESAAASCPPIHTRATPKPILTQESRGTERFQNSGGFQ 196

  Fly   135 ---------------------------------------AGSLDFEEE----------------- 143
                                                   :|..|.|||
Zfish   197 DSYAHAQILPPSSSSSCSSSMGGNNGRREERGMALKHNPSGYKDLEEEEDSWAGPVTLEEVETDI 261

  Fly   144 -----------------------------------HEVPKLLSKSLLRRL--------------- 158
                                               |...||..:..||.:
Zfish   262 IGRDNEGEDLERADLTLNPSSAPANSKGNGTPIGGHSKNKLKKRFSLRSVGRSVRGSVRGILHWR 326

  Fly   159 ------------------SFK---GLRKGK---------------ISLLQAFFHKNSDDLD---- 183
                              |:.   ||:.||               :||..:..|.:|..|.
Zfish   327 SSSSDSPQNCSNSSPLPSSYSYTTGLQDGKRNSGSQGVPSSLPVSLSLPLSLPHSSSSSLPPSSS 391

  Fly   184 ---------------GSGGSGKQSK---------------------------------------- 193
                           .|.|.|::.|
Zfish   392 SSATSLSLSEARDWRRSNGDGEKEKWSHRLEKLRLSRSPPPNLSSAAPPSSVLSPSSLPPSSINA 456

  Fly   194 -TKLAKIVVECRKEGTVNNLT------------------------------PESLDQPTGSQ--K 225
             .|:.::|    :||.|...:                              |.::....|.:  :
Zfish   457 SRKMGRLV----REGGVTVCSSSDEFASTHGFPGFSFGLLHHGADSSVSGHPTAIGGAVGGRGTR 517

  Fly   226 WEKCRLVLVK-----AVGG--YMLEFYTPHKATKPRSGVFCFLISEARETTALEMPDRLNTFVLK 283
            |.||||||.:     ..||  |.||||.|.|::|||..|.|..|.:.|.|||:|:||:.|||:|:
Zfish   518 WHKCRLVLKERDKDGGDGGLEYFLEFYIPPKSSKPRLTVPCCSIVDVRSTTAIEVPDKENTFLLQ 582

  Fly   284 ADNNMEYVIEAESAEEMRSWLATIR--YCMRTPPTQQPTIESDGVMASAMQTSPTLP------SP 340
            .:..::||||...|.:||:||:.||  .|:    ::|..:  |||..||:......|      |.
Zfish   583 MEGQVQYVIETRDAVQMRAWLSDIRNAICL----SEQEDV--DGVCGSALTDLSGTPEFSDRLSQ 641

  Fly   341 NPIGGIQNPQYQQQRGSNGNLVGGGAPLTSSL-----------SADS-ALGQGGATSASELNVIN 393
            ...||:                 ||:|....|           .:|| .||.|||:
Zfish   642 VCYGGV-----------------GGSPQLEPLPPELPPRAPLDESDSRLLGGGGAS--------- 680

  Fly   394 ELGTSPTSGPPDIPVRPHRGEQRLSASSNFDGIEGTENDADVADLTAE--MSVFPWFHGTLTRSE 456
             ||| |.:..||             |:.:|     ..:|..|:: |.|  :|...||||||:|.:
Zfish   681 -LGT-PFAETPD-------------ATGSF-----LFSDVSVSE-TVEHPLSECQWFHGTLSRLK 724

  Fly   457 AARMVLHSDAAGHGYFLVRQSETRRGEFVLTFNFQGRAKHLRLTISEKGQCRVQHLWFPSIQEML 521
            ||::||....|.||.||||||||||||:||||||||:||||||:::|.||||||||||.||.:||
Zfish   725 AAQLVLAGGMASHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEDGQCRVQHLWFQSIFDML 789

  Fly   522 EHFRHNPIPLESGGTSDVTLTEWVHSHSRLNDPTTAANHDSGQLNDLSTNGNGNGNGNGYDNGQG 586
            ||||.:||||||||.|||||..:|.: :.:..|            ||::.
Zfish   790 EHFRVHPIPLESGGASDVTLISFVGA-TNVRQP------------DLTSR--------------- 826

  Fly   587 SSTASNAAGGTASGAAGGGHPSPRHCNEVITMNLSVRLKTNEIELPQEPTHVYFPEQVYFHLDPT 651
                                  ||                   ..||.|              |.
Zfish   827 ----------------------PR-------------------SPPQPP--------------PP 836

  Fly   652 TLTVHGSPPPAQNFLDQPHLRASNASLQAAAHHQAGSSGNRHPSDGGSNSGGAGGGSGSSGGAEC 716
            .|.....|||..                              |.:.|.....||||..|||..||
Zfish   837 PLPPGRPPPPTP------------------------------PQERGPEPEVAGGGGASSGAEEC 871

  Fly   717 -----------------------TGRAVDNQYSF 727
                                   ..||:||||||
Zfish   872 EEREREPALLQLEGVEGEEREGGRARAIDNQYSF 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lnk	NP_001287536.1	Phe_ZIP	67..125	CDD:286060	24/63 (38%)
		PH_SH2B_family	202..313	CDD:269938	50/151 (33%)
		PH	220..312	CDD:278594	46/102 (45%)
		SH2_SH2B_family	438..534	CDD:198209	67/97 (69%)
sh2b1	NP_001103925.1	Phe_ZIP	71..125	CDD:286060	23/58 (40%)
		PH_SH2B_family	490..613	CDD:269938	47/126 (37%)
		PH	511..610	CDD:278594	45/98 (46%)
		SH2_SH2B_family	707..802	CDD:198209	66/94 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595674
Domainoid	1	1.000	127	1.000	Domainoid score	I5315
eggNOG	1	0.900	-	-		E1_2CN0G
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2650
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255086at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25121
orthoMCL	1	0.900	-	-		OOG6_107031
Panther	1	1.100	-	-	LDO	PTHR10872
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.760