Protein Alignment Lnk and Sh2b2

DIOPT Version :10

• Sequence 1: NP_001287536.1
• Gene: Lnk / 43130
• FlyBaseID: FBgn0028717
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_061295.2
• Gene: Sh2b2 / 23921
• MGIID: 1345171
• Length: 621
• Species: Mus musculus
• Alignment Length: 769
• Identity: 217/769 - (28%)
• Similarity: 325/769 - (42%)
• Gaps: 226/769 - (29%)

  Fly    32 TSSAAAAAAAGSDLIPAPIGTGNAMGVSSYAYGGTSWEEFCERHARVAASDFAKACITYINGNLP 96
            |.|:|||        |||:               ..|.:|||.||:|||.|||.....::..|
Mouse     5 TPSSAAA--------PAPV---------------PDWRQFCELHAQVAAVDFAHKFCRFLRDN-- 44

  Fly    97 PEEARNIQHRSFAQKFVESFSAHYDTEFFKRRSTLKSGAGSLDFEEEHEVPKLLS-KSLLRRLSF 160
            |.........||::.|..:|.|.:..|.   |..|.|.|.:::.|     |.:.| .|.|:..::
Mouse    45 PTYDTPDAGTSFSRHFAANFLAVFSEEV---RRVLGSAADTMEPE-----PAVTSVTSALKTATY 101

  Fly   161 --------------------KGLRKGKISL-----LQAFFHKNSDDLDGSGGSGKQ--------- 191
                                ||.....:||     ::..:|:.|......|.:.|.
Mouse   102 GHSRSSEDVSAHAATKARVRKGFSLRNMSLCVVDGVRDLWHRRSSPEPDGGATPKAAEPASEPRD 166

  Fly   192 --------SKTKLAKI-VVECRKEGTVN-NLTPESLDQPTGSQKWEKCRLVLVKAVGG--YMLEF 244
                    ::|..||: :|:.::||.:. .:..::...|.|:.:|:||||:|.:||.|  :.|||
Mouse   167 KWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEF 231

  Fly   245 YTPHKATKPRSGVFCFLISEARETTALEMPDRLNTFVLKADNNMEYVIEAESAEEMRSWLATIRY 309
            :.|.||::|:..:....|.|.|.|..||||::.||||||.:|..||::|...:.:..||:|.|:.
Mouse   232 FVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQG 296

  Fly   310 CMRTPPTQQPT---IESDGVMAS-------AMQTSPTLPSP----NPIGGIQNPQYQQQRGSNGN 360
            |:....:::.|   ....|.:||       .:.|...:|.|    ..:|.:....:.:.|.:.|.
Mouse   297 CVDPGDSEEDTGLSCARGGCLASRVASCSCELLTDADMPRPPETTTAVGAVVTAPHGRARDTVGE 361

  Fly   361 LVGGGAPLTSSLSADSALGQGGATSASELNVINELGTSPTSGPPDIPVRPHRGEQRLSASSNFDG 425
            .: ...||.:.|....:.|                |.|..:.|.|
Mouse   362 SL-AHVPLETFLQTLESSG----------------GVSENNNPGD-------------------- 389

  Fly   426 IEGTENDADVADLTAEMSVFPWFHGTLTRSEAARMVLHSDAAGHGYFLVRQSETRRGEFVLTFNF 490
             ||.|.|.| |:...|:|.:|||||||:|.:||::||......||.|::||||||.||.||||||
Mouse   390 -EGAELDTD-AEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNF 452

  Fly   491 QGRAKHLRLTISEKGQCRVQHLWFPSIQEMLEHFRHNPIPLESGGTSDVTLTEWVHSHSRLNDPT 555
            ||:||||||:::..|||.||||||.|:.:||.||..:||||||||::|:||..:|.:.....||.
Mouse   453 QGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPG 517

  Fly   556 TAAN----------HDSGQ--LNDLSTNGNGNGNGNGYDNGQGSSTASNAAGGTASGAAGGGHPS 608
            .|.|          ..:||  .:.|:|......:.:   ||.|:|::|    |::|.|.
Mouse   518 PAPNTAAPVPACWTEPAGQHYFSSLATATCPPASPS---NGAGASSSS----GSSSSAT------ 569

  Fly   609 PRHCNEVITMNLSVRLKTNEIELPQEPTHVYFPEQVYFHLDPTTLTVHGSPPPAQNFLDQPHLRA 673
                                 .||..|..             ..|:.|......::.||
Mouse   570 ---------------------SLPPRPAE-------------GPLSAHSRSNSTEHLLD------ 594

  Fly   674 SNASLQAAAHHQAGSSGNRHPSDGGSNSGGAGGGSGSSGGAECTGRAVDNQYSF 727
                        |.|.....|::            .:.|.|    |||:|||||
Mouse   595 ------------AASGATEEPTE------------ATLGRA----RAVENQYSF 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lnk	NP_001287536.1	Phe_ZIP	67..125	CDD:462631	20/57 (35%)
		PH_SH2B_family	202..313	CDD:269938	43/113 (38%)
		SH2_SH2B_family	438..534	CDD:198209	58/95 (61%)
Sh2b2	NP_061295.2	Phe_ZIP	17..73	CDD:462631	20/60 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	143..166		3/22 (14%)
		PH_SH2B_family	186..301	CDD:269938	43/114 (38%)
		SH2_SH2B2	401..496	CDD:198274	58/94 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..528		5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..611		19/138 (14%)