DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lnk and FES

DIOPT Version :9

Sequence 1:	NP_001287536.1	Gene:	Lnk / 43130	FlyBaseID:	FBgn0028717	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_001996.1	Gene:	FES / 2242	HGNCID:	3657	Length:	822	Species:	Homo sapiens

Alignment Length:	626	Identity:	129/626 - (20%)
Similarity:	210/626 - (33%)	Gaps:	191/626 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 EEFCERHA----------RVAASDFAKACITYINGNLPPEEARNIQHRSFAQ-KFVES---FSAH 119
            :|..:.|:          |..|.|.|:|...|       :||...:.|..|: |:|.|   ..||
Human   125 QELTKTHSQDIEKLKSQYRALARDSAQAKRKY-------QEASKDKDRDKAKDKYVRSLWKLFAH 182

  Fly   120 YDTEFFKRRSTLKSGAGSLDFEEEHEVPKLLSKSLLRRLSFKGLRKGKI----SLLQAFFHKNSD 180
            ::      |..|...|..|..:..|:   ||...|||  |.:.|.:...    .:||.:...:|.
Human   183 HN------RYVLGVRAAQLHHQHHHQ---LLLPGLLR--SLQDLHEEMACILKEILQEYLEISSL 236

  Fly   181 DLDGSGGSGKQSKTKLAKIVVEC------RKEGTVNNLTP-----ESLDQPTGSQKWEKCRLVLV 234
            ..|......::.....|:|..|.      |:.|:..::.|     |||
Human   237 VQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESL----------------- 284

  Fly   235 KAVGGYMLEFYTPHKATKPRSGVFCFLISEARETTALEMPDRLNTFVLKADNNMEYVIEAESAEE 299
                   ||...|   .:|.......|..|:.:.|...:.|.|...........|.|.:.:  :|
Human   285 -------LEEGEP---LEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQ--QE 337

  Fly   300 MRSWLATIRYCMRTPPTQQPTIESDGVMASAMQTSPTLPSPNPIGGIQ-------NPQYQQQ-RG 356
            :|:......     |..:...:....|:..|:|            |:|       ..|.||: ..
Human   338 LRNEEENTH-----PRERVQLLGKRQVLQEALQ------------GLQVALCSQAKLQAQQELLQ 385

  Fly   357 SNGNLVGGGAPLTSSLSADSALGQGGATSASELNVINELGTSPT--------SG--------PPD 405
            :....:|.|.|....|..|..    .:||:||..  .|.|.:||        ||        ||.
Human   386 TKLEHLGPGEPPPVLLLQDDR----HSTSSSEQE--REGGRTPTLEILKSHISGIFRPKFSLPPP 444

  Fly   406 IPVRPHRGEQRLSASSNFDGIEGTENDADVADLTAEMSVFPWFHGTLTRSEAARMVLHSDAAGHG 470
            :.:.|                          ::...:....|:||.:.|:|.|.:::||     |
Human   445 LQLIP--------------------------EVQKPLHEQLWYHGAIPRAEVAELLVHS-----G 478

  Fly   471 YFLVRQSETRRGEFVLTFNFQGRAKHLRLTISEKGQCRVQHLWFPSIQEMLEHF--RHNPIPLES 533
            .||||:|:.:: |:||:..:.|..:|. :..|.....|::...||||..:::|.  ...|:..:|
Human   479 DFLVRESQGKQ-EYVLSVLWDGLPRHF-IIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKS 541

  Fly   534 GGT--SDVTLTEWVHSHSRLNDPTTAANHDSGQLNDLSTNGNGNGNGNGYDNGQGSSTASNAAGG 596
            |..  ..|...:||.:|..|                  ..|...|.||..:...|...|.|....
Human   542 GVVLHRAVPKDKWVLNHEDL------------------VLGEQIGRGNFGEVFSGRLRADNTLVA 588

  Fly   597 TASGAAGGGHPSPRHCNEVITMNLSVRLKTNEIELPQEPTH 637
            ..|            |.|.:..:|..:. ..|..:.::.:|
Human   589 VKS------------CRETLPPDLKAKF-LQEARILKQYSH 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lnk	NP_001287536.1	Phe_ZIP	67..125	CDD:286060	17/69 (25%)
		PH_SH2B_family	202..313	CDD:269938	20/121 (17%)
		PH	220..312	CDD:278594	13/91 (14%)
		SH2_SH2B_family	438..534	CDD:198209	27/97 (28%)
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300		46/219 (21%)
		F-BAR_Fes	7..239	CDD:153369	32/131 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421		10/32 (31%)
		SH2_Fps_family	453..537	CDD:198224	26/90 (29%)
		Pkinase_Tyr	561..814	CDD:285015	14/87 (16%)
		PTKc_Fes	564..815	CDD:270667	13/66 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000