DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lnk and sh2b3

DIOPT Version :9

Sequence 1:	NP_001287536.1	Gene:	Lnk / 43130	FlyBaseID:	FBgn0028717	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_017211718.1	Gene:	sh2b3 / 101884640	ZFINID:	ZDB-GENE-041210-359	Length:	656	Species:	Danio rerio

Alignment Length:	824	Identity:	202/824 - (24%)
Similarity:	284/824 - (34%)	Gaps:	354/824 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 WEEFCERHARVAASDFAKACITYINGN-----LPPEEARNIQHRSFAQKFVESFSAHYDTEFFKR 127
            |.||||.||...|.:.|:....::...     :|||        ||:::|...|..|:..|..|.
Zfish    22 WREFCELHASTTARELAQHYRRFVRERPVQDVVPPE--------SFSKQFSALFQHHFSCEVAKN 78

  Fly   128 ------------------RSTLKSGAGSLDFEEEHEVPKLLS---------------KSLLR--- 156
                              |..:.|.:|.||:.|......|::               :.|||
Zfish    79 AELSLRPPPPPPLLPMTSRLRITSFSGVLDYRETVRPAPLVAILAPKPDASGVPREQEQLLRCSP 143

  Fly   157 ---------------RLSFKGLRKG----------------------KISLLQAF-----FHKNS 179
                           |..|:...:|                      :.|:.:.|     |.::|
Zfish   144 PDTTHRTRNHSQENERSDFRTGSEGYSPTACDFPSRNDVTHISVSRIRESVCRLFKKSPQFGESS 208

  Fly   180 -----DDLDGSGGSGKQSKTKLAKIVVECR----------------------------------- 204
                 |:|..|||         ..:.|||.
Zfish   209 SCCPRDELIPSGG---------PPVSVECTPHSPPVQVPTNRTSQRAALWERWNPWRTVRRRQEF 264

  Fly   205 ----KEGTVNNLTPESLDQPTGSQKWEKCRLVLVK-----AVGGYMLEFYTPHKATK-PRSGVFC 259
                |||.:..|..:.....|..| |::|||.:.:     |...|:||.|.|.|..: |:..|.|
Zfish   265 GSVCKEGQLRYLEVDDTISDTAPQ-WQRCRLQVRRTNEHSASQRYLLELYDPPKDYRMPKISVHC 328

  Fly   260 FLISEARETTALEMPDRLNTFVLK-ADNNMEYVIEAESAEEMRSWLATIRYCMRTPPTQQPTIES 323
            ..|.|.|....|||||.:|||||| |.....::.||::.:::.||...:|.||.:        .|
Zfish   329 SDIKEIRRCNRLEMPDNMNTFVLKVAGLTGGFIFEADNEQQVSSWTTELRECMSS--------RS 385

  Fly   324 DGVMASAMQTSPTLPSPNPIGGIQNPQYQQQRGSNGNLVGGGAPLTSSLSADSALGQGGATSASE 388
            |.|.......|.:|.:             .:|||:.  .||.:||...|:
Zfish   386 DNVDGEPFPVSDSLSA-------------ARRGSSD--PGGQSPLGFGLA--------------- 420

  Fly   389 LNVINELGTSPTSGPPDIPVRPHRGEQRLSASSNFDGIEGTENDADVADLTAEMSVFPWFHGTLT 453
                                     ||..:.:.:|                  :|.:.||||.::
Zfish   421 -------------------------EQAYNKTHHF------------------LSSYSWFHGPIS 442

  Fly   454 RSEAARMVLHSDAAGHGYFLVRQSETRRGEFVLTFNFQGRAKHLRLTISEKGQCRVQHLWFPSIQ 518
            |..||.:|.|:..:|||.|||||||||||::|||||:|||||||||:::|.||||||||.|||:.
Zfish   443 RVRAAYLVQHAGVSGHGNFLVRQSETRRGDYVLTFNYQGRAKHLRLSLTEWGQCRVQHLRFPSVM 507

  Fly   519 EMLEHFRHNPIPLESGGTSDVTLTEWVHSHSRLNDPTTAANHDSGQLNDLSTNGNGNGNGNGYDN 583
            :||.|||:.|||||.|...||.|..:|    |:| ||                          ..
Zfish   508 DMLSHFRNCPIPLECGAACDVMLANYV----RVN-PT--------------------------HT 541

  Fly   584 GQGSSTASNAAGGTASGAAGGGHPSPRHCNEVITMNLSVRLKTNEIELPQEPTHVYFPEQVYFHL 648
            ||.|:..|..   ....:.....||..||:                  |....|
Zfish   542 GQSSAFGSPV---LVPFSRWSSEPSLAHCS------------------PDSCPH----------- 574

  Fly   649 DPTTLTVHGSPPPA--------QNFLDQPHLRASNASLQAAAHHQAGSSGNRH------------ 693
            ..:::....|||.:        .:||...|          |..|::.|.|.|:
Zfish   575 SSSSMAQSCSPPSSLAGLSHRTPSFLPDRH----------APLHRSESVGRRNLLRHPNPLPPLL 629

  Fly   694 ----------PSDGGSNSGGAGGGSGSSGGAECTGRAVDNQYSF 727
                      |.|.|..                  ||:||||.|
Zfish   630 PNRDSDYELEPPDRGRK------------------RAIDNQYMF 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lnk	NP_001287536.1	Phe_ZIP	67..125	CDD:286060	18/61 (30%)
		PH_SH2B_family	202..313	CDD:269938	44/156 (28%)
		PH	220..312	CDD:278594	37/98 (38%)
		SH2_SH2B_family	438..534	CDD:198209	60/95 (63%)
sh2b3	XP_017211718.1	Phe_ZIP	21..76	CDD:286060	18/61 (30%)
		PH_SH2B_family	266..384	CDD:269938	42/126 (33%)
		PH	269..382	CDD:278594	41/113 (36%)
		SH2	427..523	CDD:301589	61/113 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595672
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255086at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10872
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5113
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.940