Protein Alignment Lnk and sh2b1

DIOPT Version :9

• Sequence 1: NP_001287536.1
• Gene: Lnk / 43130
• FlyBaseID: FBgn0028717
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: XP_031748811.1
• Gene: sh2b1 / 101730577
• XenbaseID: XB-GENE-13579827
• Length: 674
• Species: Xenopus tropicalis
• Alignment Length: 787
• Identity: 236/787 - (29%)
• Similarity: 348/787 - (44%)
• Gaps: 224/787 - (28%)

  Fly    42 GSDLIPAPIGTGNAMGVSSYAYGGTSWEEFCERHARVAASDFAKACITYINGNLPPEEARNIQHR 106
            ||...|:|                 :|:||||.||..||.|||:...|:::.|  |:.|......
 Frog    10 GSSCSPSP-----------------NWKEFCEIHAHAAALDFARRFRTFLSEN--PQYATPGAES 55

  Fly   107 SFAQKFVESFSAHYDTEFFKRR------------------------------------------- 128
            :|:::|.|.|..|::||..|.:
 Frog    56 NFSRRFAEHFVEHFETEVNKSQVGDGPSPNRCSIAPFTGVQSSNRDLSETCSDSSLASPVETQPR 120

  Fly   129 ---STLKSGAGSLDFEEEHEV--------PKLLSKSLLRRLSFKGLRKGKISLLQAFFHKNSDDL 182
               |.:.||..|.......:|        |:|..:..||.:| :.:|.....:||......|...
 Frog   121 QDSSGITSGLSSSQSHSSEDVSTSSATAKPRLKKRFSLRNVS-RSVRGSVRGILQWKSSAESPTE 184

  Fly   183 DGSGGS-----------GKQSKTKLAKI-----------VVECRKEGTVNNLTPESLDQPTGSQK 225
            :.||.:           |::...:..|:           :.:.|:||.:|.:..|.::  :...:
 Frog   185 ETSGANSNCNSSASRAGGERWTHRFEKLRLSRPPPHRTELRDVRREGVLNFVMAEEVN--SSRAR 247

  Fly   226 WEKCRLVLVKAVG----GYMLEFYTPHKATKPRSGVFCFLISEARETTALEMPDRLNTFVLKADN 286
            |:||||:|.|:.|    ||:||||.|.||||||..:.|..|.:.|.||.|||||:.||||||.::
 Frog   248 WQKCRLLLRKSGGDQTEGYLLEFYIPPKATKPRLSILCSSIVDVRTTTPLEMPDKENTFVLKTES 312

  Fly   287 NMEYVIEAESAEEMRSWLATIRYCM----RTPPTQQPTIESDGVMASAMQTSPTLPSPNPIGGIQ 347
            :.||::|:..:.:|:|||:.|..||    .|..|..|.|.....|.|  :..|.:||       :
 Frog   313 SSEYILESVDSLQMKSWLSDIEDCMISRTGTEATDLPHINHSESMPS--RDLPLIPS-------E 368

  Fly   348 NPQYQQQRGSNGNLVGGGAPLTSSLSADSALGQGGATSASELNVINELGTSPTSGPPDIPVR-PH 411
            :.::..| |:.|.|  ...| ::|:|..|.     :.:.|..:.:..|       ||::|.| |.
 Frog   369 SSEHLCQ-GAYGGL--SDRP-SASISPSSV-----SMTPSHFDSMELL-------PPELPPRAPI 417

  Fly   412 RGEQRL--------------SASSNFDGIEGTENDADVADLTAEMSVFPWFHGTLTRSEAARMVL 462
            ...:||              :|...|.|      :|:..|....:|.:.||||||:|.:||::||
 Frog   418 DENERLPNPMGAPFPDTPDNAAPFLFQG------EAEPGDGEHPLSEYQWFHGTLSRLKAAQLVL 476

  Fly   463 HSDAAGHGYFLVRQSETRRGEFVLTFNFQGRAKHLRLTISEKGQCRVQHLWFPSIQEMLEHFRHN 527
            ....:.||.||||||||||||:||||||||:||||||:::|.||||||||||.:|.:||||||.:
 Frog   477 AGGTSSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEDGQCRVQHLWFQTIFDMLEHFRVH 541

  Fly   528 PIPLESGGTSDVTLTEWVHSHSRLNDPTTAANHDSGQLNDLSTNGNGNGNGNGYDNGQGSSTASN 592
            ||||||||:|||||..:|.|..||::..::::.:...|..
 Frog   542 PIPLESGGSSDVTLISYVVSSQRLHEVPSSSSRNPPPLPP------------------------- 581

  Fly   593 AAGGTASGAAGGGHPSPRHCNEVITMNLSVRLKTNEIELPQEPTHVYFPEQVYFHLDPTTLTVHG 657
                         ||...|           |.....::.|..|.....|::        .|.:..
 Frog   582 -------------HPLSLH-----------RGADGAVQPPWYPLSSSPPDE--------ALGIRP 614

  Fly   658 SP--PPAQNFLDQPHLRASNASLQAAAHHQAGSSGNRHPSDGGSNSGGAGGGSGSSGGAECTGRA 720
            :|  |.||:  ::..........:||.|.|     ..||      .||:...:..||.|....||
 Frog   615 TPELPAAQH--EEERAPPMEEQEEAAVHLQ-----QLHP------GGGSSEDTSDSGSAASRARA 666

  Fly   721 VDNQYSF 727
            |:|||||
 Frog   667 VNNQYSF 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lnk	NP_001287536.1	Phe_ZIP	67..125	CDD:286060	23/57 (40%)
		PH_SH2B_family	202..313	CDD:269938	52/118 (44%)
		PH	220..312	CDD:278594	47/99 (47%)
		SH2_SH2B_family	438..534	CDD:198209	63/95 (66%)
sh2b1	XP_031748811.1	Phe_ZIP	19..73	CDD:401022	22/55 (40%)
		PH_SH2B_family	226..337	CDD:269938	50/112 (45%)
		SH2_SH2B_family	452..548	CDD:198209	63/95 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255086at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010