Protein Alignment Lnk and sh2b2

DIOPT Version :10

• Sequence 1: NP_001287536.1
• Gene: Lnk / 43130
• FlyBaseID: FBgn0028717
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: XP_009289692.1
• Gene: sh2b2 / 100535524
• -ID: -
• Length: 645
• Species: Danio rerio
• Alignment Length: 783
• Identity: 221/783 - (28%)
• Similarity: 312/783 - (39%)
• Gaps: 281/783 - (35%)

  Fly    68 WEEFCERHARVAASDFAKACITYINGN----LPPEEARNIQHRSFAQKFVESFSAHYDT------ 122
            |:||||.|||.:|:|||.....:|..|    .|..:....||  |||.|:..|||..|.
Zfish    20 WKEFCELHARASAADFAYKFRRFITENPCYDSPGADVSFSQH--FAQHFLTCFSAALDQLQDPGS 82

  Fly   123 --------------------------EFFKRR----------STLKSGAGSLDFEEEHEVP--KL 149
                                      :.:.||          .::.||||.    :|.:.|  |:
Zfish    83 PGHTSAPKYSIVPFVGIQSCTLPFSHDLYHRRKDVGASSESLDSMDSGAGG----QEQQTPTRKM 143

  Fly   150 LSKSL----------LRRLSFK---GLRKGKISL---LQAFFHKN-SDDLDGSGGS----GKQS- 192
            .:.|.          .|:..||   .||...:|:   ::..:|:. |.:.|.||.|    |.:|
Zfish   144 ATVSQSRSSEDVSLGRRKTRFKKGFSLRNMSLSVVDGVKEIWHRRASPEPDPSGSSRRTNGAESM 208

  Fly   193 ------------------KTKLAKIVVECRKEGTVNNLTPESLDQPTGSQKWEKCRLVLVKAVG- 238
                              ||:|    :|.::||.:..:..:..: ..|:.:|:||||:|.|...
Zfish   209 GSEHWSQKLRLPRGTQGHKTEL----LEIQREGALRYMVADDTN-CMGAAQWQKCRLLLRKTTAY 268

  Fly   239 -----GYMLEFYTPHKATKPRSGVFCFLISEARETTALEMPDRLNTFVLKADNNMEYVIEAESAE 298
                 .:.||||.|.|::||:..|....|.|.|.|..|||||:.||||||.:|..||::|...:.
Zfish   269 VEPGEKFQLEFYVPPKSSKPKVSVPLSAIVEVRTTMPLEMPDKDNTFVLKVENGAEYILETIDSL 333

  Fly   299 EMRSWLATIRYCMRTPPTQQPTIESDGV-MASAMQTSPTLPSPNPIGGIQNPQYQQQRGSNGNLV 362
            :..||:|.|:.|:      .|....|.: :||...:.|    |....
Zfish   334 QKNSWVADIQDCI------DPGDSGDDIELASCAHSQP----PKDFS------------------ 370

  Fly   363 GGGAPLTSSLSAD---------SALG-QGGATSASELNVINELGTSPTSGPPDIPVR-----PHR 412
                 |.||.|.:         ||.| |..|....|..|        |..|..:|:.     |.
Zfish   371 -----LVSSCSCELLCDGSHRGSAAGDQSSAARCQEPPV--------TQHPSHVPLERFLQSPE- 421

  Fly   413 GEQRLSASSNFDGIEGTENDADVADLTAEMSVFPWFHGTLTRSEAARMVLHSDAAGHGYFLVRQS 477
             .|..:.:|...|....|.:.|     |.:|.:|||||||:|..||::||...|..||.|::|||
Zfish   422 -AQNTNTASGSPGETPREGEGD-----ASLSGYPWFHGTLSRVRAAQLVLAGGARSHGLFVIRQS 480

  Fly   478 ETRRGEFVLTFNFQGRAKHLRLTISEKGQCRVQHLWFPSIQEMLEHFRHNPIPLESGGTSDVTLT 542
            |||.||:||||||||:||||||::::.|||.|.||||.::.:||.||..:||||||||::|:||.
Zfish   481 ETRPGEYVLTFNFQGKAKHLRLSVNDSGQCHVHHLWFQTVADMLRHFHTHPIPLESGGSTDITLR 545

  Fly   543 EWVHSHSRLNDPTTA-------ANHDSGQLNDLSTNGNGNGNGNGYDNGQGSSTASNAAGGTASG 600
            .:|...   ..||.|       |..|.......||:                         ..||
Zfish   546 SYVQVQ---RSPTDAVAPHVPVAPRDPSACRSESTH-------------------------PPSG 582

  Fly   601 AAGGGHPSPRHCNEVITMNLSVRLKTNEIELPQEPTHVYFPEQVYFHLDPTTLTVHGSPPPAQNF 665
            ||                                               .|.|:...|..|
Zfish   583 AA-----------------------------------------------ETPLSSSSSSSP---- 596

  Fly   666 LDQP----HLRASNAS--LQAAAHHQAGSSGNRHPSDGGSNSGGAGGGSGSSGGAECTGRAVDNQ 724
            :.||    |.|:::|.  |:.||   |.::.:.|.:||...:                 |||:||
Zfish   597 MAQPSTGLHSRSNSAERLLEPAA---AATADDYHDTDGTRRT-----------------RAVENQ 641

  Fly   725 YSF 727
            |||
Zfish   642 YSF 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lnk	NP_001287536.1	Phe_ZIP	67..125	CDD:462631	25/92 (27%)
		PH_SH2B_family	202..313	CDD:269938	44/116 (38%)
		SH2_SH2B_family	438..534	CDD:198209	57/95 (60%)
sh2b2	XP_009289692.1	Phe_ZIP	19..72	CDD:462631	22/53 (42%)
		PH_SH2B_family	232..349	CDD:269938	44/123 (36%)
		SH2_SH2B2	441..537	CDD:198274	58/100 (58%)