DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lnk and sh2b2

DIOPT Version :9

Sequence 1:	NP_001287536.1	Gene:	Lnk / 43130	FlyBaseID:	FBgn0028717	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_002942312.2	Gene:	sh2b2 / 100488327	XenbaseID:	XB-GENE-494880	Length:	667	Species:	Xenopus tropicalis

Alignment Length:	770	Identity:	217/770 - (28%)
Similarity:	322/770 - (41%)	Gaps:	230/770 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 WEEFCERHARVAASDFAKACITYI----NGNLPPEEARNIQHRSFAQKFVESFS----------- 117
            |:||||.||:.||.|||:....::    :.|.|..|.....|  ||..|::.||
Frog    17 WKEFCELHAQAAAVDFAQKFCRFLKENPHYNAPGAETSFSHH--FAANFLDFFSFEVSRVYVSDS 79

  Fly   118 -AHYD---------------TEFFKRRSTLKSGAGSLDFEEEHEVPKLLSKSLLR--RLSFKG-- 162
             ..|:               ..|..|:.  ::...|||..:.....:.||::..|  ::|..|
Frog    80 PTKYNIVPFVGLQNCQVPLARNFVPRKE--ETSTESLDSMDNPVTNRYLSRTQARVHKVSSYGHS 142

  Fly   163 ---------------LRKG----KISL-----LQAFFHKNSD---DLDG-----------SGGSG 189
                           .:||    .:||     ::..:|:.|.   .||.           :.||.
Frog   143 RSSEDVSVHDSSKSKFKKGFSLRNMSLCVVDGVKEMWHRKSSPEPSLDNGTIRRSDREHCTSGSK 207

  Fly   190 KQ-------------SKTKLAKI-VVECRKEGTVNNLTPESLDQPTGSQKWEKCRLVLVKAV--- 237
            :.             ||.:.:|| ||:.::|||:..:..:. ....||.:|:||||:|.|||
Frog   208 EHVEPREKWTQKLRLSKMQASKIDVVDIQREGTLRYMVADD-SNCVGSSQWQKCRLLLRKAVKME 271

  Fly   238 -GGYMLEFYTPHKATKPRSGVFCFLISEARETTALEMPDRLNTFVLKADNNMEYVIEAESAEEMR 301
             ..::||||.|.|::||:..:....|.|.|.|..|||||:.||||||.:|:.||::|...:.:..
Frog   272 GERFLLEFYVPPKSSKPKVSIPLSAILEVRTTMPLEMPDKDNTFVLKVENSAEYILETIDSLQKH 336

  Fly   302 SWLATIRYCMRTPPTQQPTIESDGVMASAMQTSPTLPSPNPIGGIQNPQYQQQRGSNGNLVGGGA 366
            ||:|.|:.|:      .|....|.:..|:.:                         .|..:.|.|
Frog   337 SWVADIQDCI------DPGDSGDDIELSSCE-------------------------QGTCLAGQA 370

  Fly   367 PLTSSLSADSALGQGG----ATSASELNVINELGTSPTSGPPD--------------IPVRPHRG 413
               ||.|.: .|..|.    .|.|::....:.:...||..||.              :|:.....
Frog   371 ---SSCSCE-FLADGSFRPLETCATDFPGASAVPPHPTCAPPQPRNRDMSSAEHLIHVPLEHFLQ 431

  Fly   414 EQRLSASSNFDGIEGTENDADVADLTAEMSVFPWFHGTLTRSEAARMVLHSDAAGHGYFLVRQSE 478
            ......|::..|.||.|      ::...:|.||||||||:|..||::||......||.|::||||
Frog   432 TLEPPTSNHLPGEEGEE------EIEINLSDFPWFHGTLSRIRAAQLVLSGGTRSHGLFVIRQSE 490

  Fly   479 TRRGEFVLTFNFQGRAKHLRLTISEKGQCRVQHLWFPSIQEMLEHFRHNPIPLESGGTSDVTLTE 543
            ||.||:||||||||:||||||:::|.|||.||||||.:|.:||:||..:||||||||::|:||..
Frog   491 TRPGEYVLTFNFQGKAKHLRLSLNETGQCHVQHLWFQTIFDMLKHFHSHPIPLESGGSADITLRS 555

  Fly   544 WVHSHSRLN-DPTTAANHDSGQLNDLSTNGNGNGNGNGYDNGQGSSTASNAAGGTASGAAGGGHP 607
            :|.:..:|: ||....|....|.|..:..     ....|....|:|.....:...:|.:|...||
Frog   556 FVVAQRQLSADPAPPQNVSVQQQNCRTET-----QSQHYFTSSGASNMQPVSPPESSASAPAPHP 615

  Fly   608 SPRHCNEVITMNLSVRLKTNEIELPQEPTHVYFPEQVYFHLDPTTLTVHGSPPPAQNFLDQPHLR 672
            :...    :...|..|.::|..||                                 .|:.|:
Frog   616 AYHR----VEGTLGTRSRSNSAEL---------------------------------LLESPN-- 641

  Fly   673 ASNASLQAAAHHQAGSSGNRHPSDGGSNSGGAGGGSGSSGGAECTGRAVDNQYSF 727
                          ||:.:.|.||                |:....|||:|||||
Frog   642 --------------GSTEDYHESD----------------GSRSRTRAVENQYSF 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lnk	NP_001287536.1	Phe_ZIP	67..125	CDD:286060	22/87 (25%)
		PH_SH2B_family	202..313	CDD:269938	46/114 (40%)
		PH	220..312	CDD:278594	43/95 (45%)
		SH2_SH2B_family	438..534	CDD:198209	59/95 (62%)
sh2b2	XP_002942312.2	Phe_ZIP	16..72	CDD:370185	21/56 (38%)
		PH_SH2B_family	234..349	CDD:269938	46/121 (38%)
		SH2_SH2B2	453..546	CDD:198274	59/92 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3337
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255086at33208
OrthoFinder	1	1.000	-	-		FOG0007413
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10872
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5113
SonicParanoid	1	1.000	-	-		X3118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.100