Protein Alignment SppL and SPPL2A

DIOPT Version :9

• Sequence 1: NP_001163740.1
• Gene: SppL / 43128
• FlyBaseID: FBgn0039381
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: XP_005254779.1
• Gene: SPPL2A / 84888
• HGNCID: 30227
• Length: 538
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 101/423 - (23%)
• Similarity: 187/423 - (44%)
• Gaps: 104/423 - (24%)

  Fly    31 EYRELHWTVSSVM------------DSSRVSTCLISMLLIVYGSFRSLNIEQE------AREREQ 77
            ::|:::.|:...:            |.:.|...:|::..:..|.:.|..:|.|      ..:||.
Human   144 DFRDMNQTLGDNITVKMYSPSWPNFDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREM 208

  Fly    78 KKRNESMTNLLTGEPVEKEPNLYFTADKFATLDTMHALCLPLGASISLLIMFFFFD----SMQLL 138
            :|:.|   ..||..|:              |:.....:|     .:.:::::||:.    .|..:
Human   209 RKKKE---EYLTFSPL--------------TVVIFVVIC-----CVMMVLLYFFYKWLVYVMIAI 251

  Fly   139 FAVCTAIIATVALAFLL--LPMCQYIIRPCT---DGKRFSFGFCGRFTAAELFSFTLSVSIVCIW 198
            |.:.:|:.....||.|:  :|..|     ||   .||......        :|...|.:::..:|
Human   252 FCIASAMSLYNCLAALIHKIPYGQ-----CTIACRGKNMEVRL--------IFLSGLCIAVAVVW 303

  Fly   199 VLTGH-----WLLMDAMGMGLCVAFIAFVRLPSLKVSTLLLTGLLIYDVFWVFLSSYIFST--NV 256
            .:..:     |:|.|.:|:..|:..|..::||:.|...:||..||:||||:||::.:|...  ::
Human   304 AVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPFITKNGESI 368

  Fly   257 MVKVATRPADNPVGIVARKLHLGGIVRDT-----PKLNLP-----GKLVFPSLHNT--GHFSMLG 309
            ||::|..|..|      .:.:.|.:|..|     |...||     .||::.|:.:.  ...|:||
Human   369 MVELAAGPFGN------NEKNDGNLVEATGQPSAPHEKLPVVIRVPKLIYFSVMSVCLMPVSILG 427

  Fly   310 LGDVVMPGLLLCFVLRYDAYKKAQGVTSDPTLSPPRGVGSRLTYFHCSLLGYFLGLLTATVSSEV 374
            .||:::||||:.:..|:|..                 .||...|:..|.:.|.:|::...|...:
Human   428 FGDIIVPGLLIAYCRRFDVQ-----------------TGSSYIYYVSSTVAYAIGMILTFVVLVL 475

  Fly   375 FKAAQPALLYLVPFTLLPLLLMAYLKGDLRRMW 407
            .|..|||||||||.||:...::|:.:.::::.|
Human   476 MKKGQPALLYLVPCTLITASVVAWRRKEMKKFW 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SppL	NP_001163740.1	Peptidase_A22B	102..413	CDD:282158	85/334 (25%)
SPPL2A	XP_005254779.1	PA_hSPPL_like	41..160	CDD:239044	2/15 (13%)
		Peptidase_A22B	210..514	CDD:282158	90/357 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810