Protein Alignment SppL and HM13

DIOPT Version :10

• Sequence 1: NP_001163740.1
• Gene: SppL / 43128
• FlyBaseID: FBgn0039381
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_848696.1
• Gene: HM13 / 81502
• HGNCID: 16435
• Length: 426
• Species: Homo sapiens
• Alignment Length: 418
• Identity: 115/418 - (27%)
• Similarity: 172/418 - (41%)
• Gaps: 115/418 - (27%)

  Fly    23 GAAAAGGGEYRELHWTVSSVMDSSRV--------STCLISMLLIVYGSFRSLNIEQEAREREQKK 79
            |:|.|||.       |.|:....|..        |..|:::|.|.:|:.||:        |..:.
Human    11 GSAEAGGP-------TNSTTRPPSTPEGIALAYGSLLLMALLPIFFGALRSV--------RCARG 60

  Fly    80 RNESMTNLLTGEPVEKEPNLYFTADKFATLDTMHALCLPLGASISLLIMFFFF-----DSMQLLF 139
            :|.|                    |...|:.:..|...|:.||.:||.::.||     :.:.||.
Human    61 KNAS--------------------DMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYINLLL 105

  Fly   140 AVCTAIIATVALAFLLLPMCQYIIRPCTDGKRFSFGFCG------------RFTAAELFSFTLSV 192
            ::...::..:||:..:.|............:::...|..            .|...:|....||
Human   106 SMYFFVLGILALSHTISPFMNKFFPASFPNRQYQLLFTQGSGENKEEIINYEFDTKDLVCLGLS- 169

  Fly   193 SIVCIW-VLTGHWLLMDAMGMGLCVAFIAFVRLPSLKVSTLLLTGLLIYDVFWVFLSSYIFSTNV 256
            |||.:| :|..||:..:..|:...:..:..:.|.::....:||.||.|||||||      |.|||
Human   170 SIVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWV------FGTNV 228

  Fly   257 MVKVATRPADNPVGIVARKLHLGGIVRDTPKLNLPGKLVFP-SLHNTG----HFSMLGLGDVVMP 316
            ||.||                        .....|.||||| .|...|    :|:||||||||:|
Human   229 MVTVA------------------------KSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIP 269

  Fly   317 GLLLCFVLRYD-AYKKAQGVTSDPTLSPPRGVGSRLTYFHCSLLGYFLGLLTATVSSEVFKAAQP 380
            |:.:..:||:| :.||                 :..|||:.|...|..||........:||.|||
Human   270 GIFIALLLRFDISLKK-----------------NTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQP 317

  Fly   381 ALLYLVPFTLLPLLLMAYLKGDLRRMWS 408
            |||||||..:...:|:|..||::..|:|
Human   318 ALLYLVPACIGFPVLVALAKGEVTEMFS 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SppL	NP_001163740.1	Peptidase_A22B	102..413	CDD:282158	97/331 (29%)
HM13	NP_848696.1	Peptidase_A22B	63..350	CDD:282158	98/351 (28%)