DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SppL and SPPL2B

DIOPT Version :9

Sequence 1:	NP_001163740.1	Gene:	SppL / 43128	FlyBaseID:	FBgn0039381	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_011526440.1	Gene:	SPPL2B / 56928	HGNCID:	30627	Length:	618	Species:	Homo sapiens

Alignment Length:	312	Identity:	88/312 - (28%)
Similarity:	142/312 - (45%)	Gaps:	76/312 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 LLIMFFFFDSMQLLFAVCTAIIATVALAFLLLPMCQYIIRPCTDGKRFSFGFC------------ 177
            |:::::|:|   ||..|...|....:...|.  .|   :.||.  :|..||.|
Human   263 LVLLYYFYD---LLVYVVIGIFCLASATGLY--SC---LAPCV--RRLPFGKCRIPNNSLPYFHK 317

  Fly   178 ---GRFTAAELFSFTLSVSIVCIWVLTGH-----WLLMDAMGMGLCVAFIAFVRLPSLKVSTLLL 234
               .|.....||...:||    :|.:..:     |:|.||:|:..|:..:..:|||:.|..||||
Human   318 RPQARMLLLALFCVAVSV----VWGVFRNEDQWAWVLQDALGIAFCLYMLKTIRLPTFKACTLLL 378

  Fly   235 TGLLIYDVFWVFLSSYI--FSTNVMVKVATRPADNPVGIVARKLHLGGIVRDTPKLNLPGKLVFP 297
            ..|.:||:|:||::.::  ..:::||:|||.|:|:                 ..:..||..|..|
Human   379 LVLFLYDIFFVFITPFLTKSGSSIMVEVATGPSDS-----------------ATREKLPMVLKVP 426

  Fly   298 SLHNT------GHFSMLGLGDVVMPGLLLCFVLRYDAYKKAQGVTSDPTLSPPRGVGSRLTYFHC 356
            .|:::      ..||:||.||:::||||:.:..|:|..                 |.|...||..
Human   427 RLNSSPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQ-----------------VQSSRVYFVA 474

  Fly   357 SLLGYFLGLLTATVSSEVFKAAQPALLYLVPFTLLPLLLMAYLKGDLRRMWS 408
            ..:.|.:|||...|:..:.:..|||||||||.||:....:|..:.:|...|:
Human   475 CTIAYGVGLLVTFVALALMQRGQPALLYLVPCTLVTSCAVALWRRELGVFWT 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SppL	NP_001163740.1	Peptidase_A22B	102..413	CDD:282158	88/312 (28%)
SPPL2B	XP_011526440.1	PA_hSPPL_like	71..190	CDD:239044
SPPL2B	XP_011526440.1	Peptidase_A22B	239..531	CDD:282158	88/312 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810