DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SppL and sppl3

DIOPT Version :9

Sequence 1:	NP_001163740.1	Gene:	SppL / 43128	FlyBaseID:	FBgn0039381	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001015068.1	Gene:	sppl3 / 548609	ZFINID:	ZDB-GENE-050913-71	Length:	382	Species:	Danio rerio

Alignment Length:	386	Identity:	252/386 - (65%)
Similarity:	308/386 - (79%)	Gaps:	18/386 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SVMDSSRVSTCLISMLLIVYGSFRSLNIEQEAREREQKKRNESMTNLLTGEPVEKEP-NLYFTAD 104
            |::|||:|||.|||:||||||||||||::.|.:|:::           .|.|..... |...:.:
Zfish    11 SLVDSSQVSTFLISILLIVYGSFRSLNMDCENQEKDK-----------DGNPTASGSFNNANSNN 64

  Fly   105 KFATLDTMHALCLPLGASISLLIMFFFFDSMQLLFAVCTAIIATVALAFLLLPMCQYIIRPCTDG 169
            ...|:|:..||.||:|||:|||:|||||||:|::|.:|||::||:|.||||||||||:.|||:..
Zfish    65 SIQTIDSTQALFLPIGASVSLLVMFFFFDSVQVVFTICTAVLATIAFAFLLLPMCQYLTRPCSPQ 129

  Fly   170 KRFSFGFCGRFTAAELFSFTLSVSIVCIWVLTGHWLLMDAMGMGLCVAFIAFVRLPSLKVSTLLL 234
            .:.|||.|||||.|||.||:|||.:|.|||||||||||||:.||||||.||||||||||||.|||
Zfish   130 NKISFGCCGRFTLAELLSFSLSVMLVLIWVLTGHWLLMDALAMGLCVAMIAFVRLPSLKVSCLLL 194

  Fly   235 TGLLIYDVFWVFLSSYIFSTNVMVKVATRPADNPVGIVARKLHLG-GIVRDTPKLNLPGKLVFPS 298
            :|||||||||||.|:|||::||||||||:|||||:.:::|||||| |:.||.|:|:|||||||||
Zfish   195 SGLLIYDVFWVFFSAYIFNSNVMVKVATQPADNPLDVLSRKLHLGPGMGRDVPRLSLPGKLVFPS 259

  Fly   299 LHNTG-HFSMLGLGDVVMPGLLLCFVLRYDAYKKAQGVTSDPTLSPPRGVGSRLTYFHCSLLGYF 362
              :|| ||||||:||:||||||||||||||.||| |.....|..:...|...|::||||:|:|||
Zfish   260 --STGSHFSMLGIGDIVMPGLLLCFVLRYDNYKK-QATGEVPGPANMSGRMQRVSYFHCTLIGYF 321

  Fly   363 LGLLTATVSSEVFKAAQPALLYLVPFTLLPLLLMAYLKGDLRRMWSEPFIAQQPSKQ-LEV 422
            :|||||||:|.:.:||||||||||||||||||.||||||||||||||||.|:..|.: |||
Zfish   322 VGLLTATVASRIHRAAQPALLYLVPFTLLPLLTMAYLKGDLRRMWSEPFHAKSSSSRFLEV 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SppL	NP_001163740.1	Peptidase_A22B	102..413	CDD:282158	220/312 (71%)
sppl3	NP_001015068.1	Peptidase_A22B	66..372	CDD:282158	220/308 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596650
Domainoid	1	1.000	444	1.000	Domainoid score	I510
eggNOG	1	0.900	-	-		E1_KOG2443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15563
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1409
OMA	1	1.010	-	-		QHG52034
OrthoDB	1	1.010	-	-		D1087991at2759
OrthoFinder	1	1.000	-	-		FOG0006910
OrthoInspector	1	1.000	-	-		oto41522
orthoMCL	1	0.900	-	-		OOG6_105316
Panther	1	1.100	-	-	LDO	PTHR12174
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1942
SonicParanoid	1	1.000	-	-		X5817
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800