DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SppL and Sppl3

DIOPT Version :9

Sequence 1:	NP_001163740.1	Gene:	SppL / 43128	FlyBaseID:	FBgn0039381	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_003751248.1	Gene:	Sppl3 / 360822	RGDID:	1562826	Length:	384	Species:	Rattus norvegicus

Alignment Length:	389	Identity:	252/389 - (64%)
Similarity:	311/389 - (79%)	Gaps:	22/389 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SVMDSSRVSTCLISMLLIVYGSFRSLNIEQEAREREQKKRNESMTNLLTGEPVEKEPNLYFTADK 105
            |::|||:|||.|||:||||||||||||::.|.:::|  |.:.|.:....|..         |.:.
  Rat    11 SLVDSSQVSTFLISILLIVYGSFRSLNMDFENQDKE--KDSSSSSGPFNGSS---------TNNS 64

  Fly   106 FATLDTMHALCLPLGASISLLIMFFFFDSMQLLFAVCTAIIATVALAFLLLPMCQYIIRPCTDGK 170
            ..|:|:..||.||:|||:|||:|||||||:|::|.:|||::||:|.||||||||||:.|||:...
  Rat    65 IQTIDSTQALFLPIGASVSLLVMFFFFDSVQVVFTICTAVLATIAFAFLLLPMCQYLTRPCSPQN 129

  Fly   171 RFSFGFCGRFTAAELFSFTLSVSIVCIWVLTGHWLLMDAMGMGLCVAFIAFVRLPSLKVSTLLLT 235
            :.|||.|||||||||.||:|||.:|.|||||||||||||:.||||||.||||||||||||.|||:
  Rat   130 KISFGCCGRFTAAELLSFSLSVMLVLIWVLTGHWLLMDALAMGLCVAMIAFVRLPSLKVSCLLLS 194

  Fly   236 GLLIYDVFWVFLSSYIFSTNVMVKVATRPADNPVGIVARKLHLG-GIVRDTPKLNLPGKLVFPSL 299
            |||||||||||.|:|||::||||||||:|||||:.:::|||||| .:.||.|:|:|||||||||
  Rat   195 GLLIYDVFWVFFSAYIFNSNVMVKVATQPADNPLDVLSRKLHLGPNVGRDVPRLSLPGKLVFPS- 258

  Fly   300 HNTG-HFSMLGLGDVVMPGLLLCFVLRYDAYKKAQGVTSDPTLSP-PRGVGSRL---TYFHCSLL 359
             :|| ||||||:||:||||||||||||||.|||.  .:.|...:| |..:..|:   :||||:|:
  Rat   259 -STGSHFSMLGIGDIVMPGLLLCFVLRYDNYKKQ--ASGDSCGAPGPANISGRMQRVSYFHCTLI 320

  Fly   360 GYFLGLLTATVSSEVFKAAQPALLYLVPFTLLPLLLMAYLKGDLRRMWSEPFIAQQPSKQ-LEV 422
            |||:|||||||:|.:.:||||||||||||||||||.||||||||||||||||.::..|.: |||
  Rat   321 GYFVGLLTATVASRIHRAAQPALLYLVPFTLLPLLTMAYLKGDLRRMWSEPFHSKSSSSRFLEV 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SppL	NP_001163740.1	Peptidase_A22B	102..413	CDD:282158	221/316 (70%)
Sppl3	XP_003751248.1	Peptidase_A22B	60..374	CDD:282158	221/326 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354365
Domainoid	1	1.000	443	1.000	Domainoid score	I514
eggNOG	1	0.900	-	-		E1_KOG2443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15563
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1395
OMA	1	1.010	-	-		QHG52034
OrthoDB	1	1.010	-	-		D1087991at2759
OrthoFinder	1	1.000	-	-		FOG0006910
OrthoInspector	1	1.000	-	-		oto96085
orthoMCL	1	0.900	-	-		OOG6_105316
Panther	1	1.100	-	-	LDO	PTHR12174
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5817
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770