DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SppL and Sppl2c

DIOPT Version :9

Sequence 1:	NP_001163740.1	Gene:	SppL / 43128	FlyBaseID:	FBgn0039381	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001099317.1	Gene:	Sppl2c / 287753	RGDID:	1560562	Length:	691	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	103/417 - (24%)
Similarity:	181/417 - (43%)	Gaps:	98/417 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VMDSSRVSTCLISMLLIVYGSFRSLNIEQEAREREQKKR-------NESMTNLLTGEPVEKEPNL 99
            ::|.:.|...::::..:..|.:.:..:|.:..:|.|.:|       |:|.|     ...|:.|..
  Rat   184 IIDYNMVIIFILAVGTVAAGGYWAGLMEADRLQRHQARRGGGFGGHNQSQT-----VSAERSPRA 243

  Fly   100 YFTAD-KFATLD---TMHALCLPLGASISLLIMFFFFDSMQLLFAVCTAIIATVALAFLLLPMCQ 160
            :...| :.|.:|   .|....:.:..|| :::::||:|....:......:.|:..|...|.|:.:
  Rat   244 WKEEDYEDAAVDFTPAMTGAVVTMSCSI-MVLLYFFYDCFVYIMIGIFGLGASTGLYSCLAPIVR 307

  Fly   161 YI-------IRPCTDGKRFSF--------GFCGRFTAAELFSFTLSVSIVCIWVLTGH-----WL 205
            |:       :.|   |.|.|.        |.|...|.              :||:..:     ||
  Rat   308 YLPLWQHQWVLP---GHRASVKLSLLLLAGLCAMVTV--------------LWVIYRNEDRWAWL 355

  Fly   206 LMDAMGMGLCVAFIAFVRLPSLKVSTLLLTGLLIYDVFWVFLSSYIFST--NVMVKVATRPADN- 267
            |.|.:|:..|:..:..||||:||..|..|..||.:|||:||::.....|  ::||:||:.|.|:
  Rat   356 LQDTLGVAYCLFVLRRVRLPTLKNCTSFLLALLAFDVFFVFITPLFTKTGESIMVEVASGPVDSS 420

  Fly   268 -----PVGIVARKLHLGGI-VRDTPKLNLPGKLVFPSLHNTGHFSMLGLGDVVMPGLLLCFVLRY 326
                 |:.:...::....: :.|.|                  ||:||.||:|:||.|:.:..|:
  Rat   421 SHERLPMVLKVPRMSFSALTLCDQP------------------FSILGFGDIVVPGFLVAYCHRF 467

  Fly   327 DAYKKAQGVTSDPTLSPPRGVGSRLTYFHCSLLGYFLGLLTATVSSEVFKAAQPALLYLVPFTLL 391
            |..                 :.||..|:....:.|.:|||...|:..:.:..||||||||..|||
  Rat   468 DVQ-----------------IQSRQVYYRACTVAYAMGLLVTFVAMVLMQMGQPALLYLVSSTLL 515

  Fly   392 PLLLMAYLKGDLRRMWSEPFIAQQPSK 418
            ..|::|..:.:|...|:....|:.|::
  Rat   516 TSLVVATCRQELTLFWTGQGRAKIPAE 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SppL	NP_001163740.1	Peptidase_A22B	102..413	CDD:282158	89/343 (26%)
Sppl2c	NP_001099317.1	Peptidases_S8_S53	40..177	CDD:299169
Sppl2c	NP_001099317.1	Peptidase_A22B	250..534	CDD:294809	88/336 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910