DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SppL and SPPL2C

DIOPT Version :9

Sequence 1:	NP_001163740.1	Gene:	SppL / 43128	FlyBaseID:	FBgn0039381	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_787078.2	Gene:	SPPL2C / 162540	HGNCID:	28902	Length:	684	Species:	Homo sapiens

Alignment Length:	417	Identity:	107/417 - (25%)
Similarity:	165/417 - (39%)	Gaps:	102/417 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AGGGLGAQTVGAGQLGGGAAAAGGGEYRELHWTVSSVMDSSRVSTCLISMLLIVYGSFRSLNIEQ 70
            |.||..|....|.:|....|..|||.                             |....|. |.
Human   199 AAGGYWAGLTEANRLQRRRARRGGGS-----------------------------GGHHQLQ-EA 233

  Fly    71 EAREREQKKRNESMTNLLTGEPVEKEPNLYFTADKFATLDTMHALCLPLGASISLLIMFFFFDSM 135
            .|.|..||:.||.:       ||:..|             .|..:.:.|..|: :|:::||:|..
Human   234 AAAEGAQKEDNEDI-------PVDFTP-------------AMTGVVVTLSCSL-MLLLYFFYDHF 277

  Fly   136 QLLFAVCTAIIATVALAFLLLPM-CQYIIRPCTDGKRFSFGFCGRFTAAELFSFTLSVSIVCIWV 199
            ..:......:.|.:.|...|.|: |:..:|   ..:|.............|...:|..:::..||
Human   278 VYVTIGIFGLGAGIGLYSCLSPLVCRLSLR---QYQRPPHSLWASLPLPLLLLASLCATVIIFWV 339

  Fly   200 LTGH-----WLLMDAMGMGLCVAFIAFVRLPSLKVSTLLLTGLLIYDVFWVFLSSYIFST--NVM 257
            ...:     |||.|.:|:..|:..:..||||:||..:..|..||.:|||:||::.:...|  ::|
Human   340 AYRNEDRWAWLLQDTLGISYCLFVLHRVRLPTLKNCSSFLLALLAFDVFFVFVTPFFTKTGESIM 404

  Fly   258 VKVATRPADNPVGIVARKLHLGGIVRDTPKLNLPGKLVFPSLHNTG------HFSMLGLGDVVMP 316
            .:||..||::                 :....||..|..|.|..:.      .||:||.||:|:|
Human   405 AQVALGPAES-----------------SSHERLPMVLKVPRLRVSALTLCSQPFSILGFGDIVVP 452

  Fly   317 GLLLCFVLRYDAYKKAQGVTSDPTLSPPRGVGSRLTYFHCSLLGYFLGLLTATVSSEVFKAAQPA 381
            |.|:.:..|:|..                 |.||..||....:.|.:|||...::..:.:..|||
Human   453 GFLVAYCCRFDVQ-----------------VCSRQIYFVACTVAYAVGLLVTFMAMVLMQMGQPA 500

  Fly   382 LLYLVPFTLLPLLLMAYLKGDLRRMWS 408
            |||||..|||..|.:|..:.:|...|:
Human   501 LLYLVSSTLLTSLAVAACRQELSLFWT 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SppL	NP_001163740.1	Peptidase_A22B	102..413	CDD:282158	85/321 (26%)
SPPL2C	NP_787078.2	PA_hSPPL_like	38..175	CDD:239044
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..242		10/55 (18%)
		PSN	247..519	CDD:214793	86/329 (26%)
		PAL	499..501		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..614
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810