DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5890 and KCNIP4

DIOPT Version :9

Sequence 1:	NP_001356889.1	Gene:	CG5890 / 43126	FlyBaseID:	FBgn0039380	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_079497.2	Gene:	KCNIP4 / 80333	HGNCID:	30083	Length:	250	Species:	Homo sapiens

Alignment Length:	204	Identity:	97/204 - (47%)
Similarity:	149/204 - (73%)	Gaps:	5/204 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASPP-ESPIEEVVYELEHTRVPKPIPVALEDLCRQTKFTKQEIRVMYRGFKTECPEGVVHEDCFK 65
            :||. ::.:|:   |||...| :..|.|||.|..|:||||:|::::|||||.|||.|||:|:.||
Human    49 SSPAIQNSVED---ELEMATV-RHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFK 109

  Fly    66 DIYAKFFPHGNSSLYAHYVFKAFDVNCNGAISFRDLLVTLSTLLRGSVYERLRWTFKLYDLNGDG 130
            :||::|||.|:|:.|||::|.|||.:.|||:||.|.:..||.||||:|.|:|.|.|.|||:|.||
Human   110 EIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDG 174

  Fly   131 RISRGELSEIILAIHELMGRRPHQPEDDRKARDQVDRVFRKLDLNQDGIITIEEFLEACLKDDLV 195
            .|::.|:.:|:.||:::||:..:....:...|..|:..|:|:|.|:||::||:||:|:|.||:.:
Human   175 YITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENI 239

  Fly   196 TRSLQMFDN 204
            .||:|:|:|
Human   240 MRSMQLFEN 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5890	NP_001356889.1	FRQ1	29..192	CDD:227455	81/162 (50%)
KCNIP4	NP_079497.2	KIS. /evidence=ECO:0000250	2..44
		FRQ1	80..239	CDD:227455	79/158 (50%)
		Interaction with KCND2. /evidence=ECO:0000250	237..250		5/12 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143242
Domainoid	1	1.000	96	1.000	Domainoid score	I7327
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1513542at2759
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	1	1.000	-	-		otm40506
orthoMCL	1	0.900	-	-		OOG6_101448
Panther	1	1.100	-	-	O	PTHR23055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5210
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.930