DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5890 and RCVRN

DIOPT Version :9

Sequence 1:	NP_001356889.1	Gene:	CG5890 / 43126	FlyBaseID:	FBgn0039380	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_002894.1	Gene:	RCVRN / 5957	HGNCID:	9937	Length:	200	Species:	Homo sapiens

Alignment Length:	176	Identity:	58/176 - (32%)
Similarity:	104/176 - (59%)	Gaps:	6/176 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LEDLCRQTKFTKQEIRVMYRGFKTECPEGVVHEDCFKDIYAKFFPHGNSSLYAHYVFKAFDVNCN 93
            ||:|...|||:::|:...|:.|..:||.|.:.:..|:.|||||||..:...||.:||::||.|.:
Human    14 LEELQLNTKFSEEELCSWYQSFLKDCPTGRITQQQFQSIYAKFFPDTDPKAYAQHVFRSFDSNLD 78

  Fly    94 GAISFRDLLVTLSTLLRGSVYERLRWTFKLYDLNGDGRISRGELSEIILAIHELMGRRPHQ---- 154
            |.:.|::.::.|.....|...::|.|.|.|||::|:|.||:.|:.||::||.:::  .|..
Human    79 GTLDFKEYVIALHMTTAGKTNQKLEWAFSLYDVDGNGTISKNEVLEIVMAIFKMI--TPEDVKLL 141

  Fly   155 PEDDRKARDQVDRVFRKLDLNQDGIITIEEFLEACLKDDLVTRSLQ 200
            |:|:.....:.:::::....|.|..:|.:||:|..|.:..:.|.:|
Human   142 PDDENTPEKRAEKIWKYFGKNDDDKLTEKEFIEGTLANKEILRLIQ 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5890	NP_001356889.1	FRQ1	29..192	CDD:227455	56/166 (34%)
RCVRN	NP_002894.1	FRQ1	14..182	CDD:227455	56/169 (33%)
RCVRN	NP_002894.1	Interaction with GRK1. /evidence=ECO:0000250\|UniProtKB:P21457	189..192
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840