DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5890 and KCNIP1

DIOPT Version :9

Sequence 1:	NP_001356889.1	Gene:	CG5890 / 43126	FlyBaseID:	FBgn0039380	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_001265268.1	Gene:	KCNIP1 / 30820	HGNCID:	15521	Length:	241	Species:	Homo sapiens

Alignment Length:	226	Identity:	104/226 - (46%)
Similarity:	143/226 - (63%)	Gaps:	29/226 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PPESPIEEVVYELEHTRVPKPIPVALEDLCRQTKFTKQEIRVMYRGFKTECPEGVVHEDCFKDIY 68
            |.:..||:   |||.|.|... |..||.|..||.|||:|::|:|||||.|||.|||:||.||.||
Human    18 PSKDKIED---ELEMTMVCHR-PEGLEQLEAQTNFTKRELQVLYRGFKNECPSGVVNEDTFKQIY 78

  Fly    69 AKFFPHG-------------------------NSSLYAHYVFKAFDVNCNGAISFRDLLVTLSTL 108
            |:|||||                         ::|.||||:|.|||....|::.|.|.:..||.|
Human    79 AQFFPHGALPCLEGSPCVEFLPPSPALLFCLVDASTYAHYLFNAFDTTQTGSVKFEDFVTALSIL 143

  Fly   109 LRGSVYERLRWTFKLYDLNGDGRISRGELSEIILAIHELMGRRPHQPEDDRKARDQVDRVFRKLD 173
            |||:|:|:|||||.|||:|.||.|::.|:.:|:.||:::||:..:....:...|..||..|:|:|
Human   144 LRGTVHEKLRWTFNLYDINKDGYINKEEMMDIVKAIYDMMGKYTYPVLKEDTPRQHVDVFFQKMD 208

  Fly   174 LNQDGIITIEEFLEACLKDDLVTRSLQMFDN 204
            .|:|||:|::||||:|.:||.:.||||:|.|
Human   209 KNKDGIVTLDEFLESCQEDDNIMRSLQLFQN 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5890	NP_001356889.1	FRQ1	29..192	CDD:227455	87/187 (47%)
KCNIP1	NP_001265268.1	FRQ1	39..230	CDD:227455	89/190 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143240
Domainoid	1	1.000	96	1.000	Domainoid score	I7327
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H22824
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3639
Isobase	1	0.950	-	0	Normalized mean entropy	S788
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606780at33208
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	1	1.000	-	-		otm40506
orthoMCL	1	0.900	-	-		OOG6_101448
Panther	1	1.100	-	-	O	PTHR23055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5210
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.880