DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5890 and KCNIP3

DIOPT Version :9

Sequence 1:	NP_001356889.1	Gene:	CG5890 / 43126	FlyBaseID:	FBgn0039380	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_038462.1	Gene:	KCNIP3 / 30818	HGNCID:	15523	Length:	256	Species:	Homo sapiens

Alignment Length:	190	Identity:	97/190 - (51%)
Similarity:	138/190 - (72%)	Gaps:	1/190 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ELEHTRVPKPIPVALEDLCRQTKFTKQEIRVMYRGFKTECPEGVVHEDCFKDIYAKFFPHGNSSL 79
            |||.:.| :..|..|:.|..||||||:|::.:|||||.|||.|:|.||.||.|||:|||.|:::.
Human    66 ELELSTV-RHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATT 129

  Fly    80 YAHYVFKAFDVNCNGAISFRDLLVTLSTLLRGSVYERLRWTFKLYDLNGDGRISRGELSEIILAI 144
            |||::|.|||.:.||||.|.|.:|.||.||||:|:|:|:|.|.|||:|.||.|::.|:..|:.:|
Human   130 YAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSI 194

  Fly   145 HELMGRRPHQPEDDRKARDQVDRVFRKLDLNQDGIITIEEFLEACLKDDLVTRSLQMFDN 204
            :::|||..:....:....:.|:|.|.|:|.||||::|||||||||.||:.:..|:|:|:|
Human   195 YDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFEN 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5890	NP_001356889.1	FRQ1	29..192	CDD:227455	86/162 (53%)
KCNIP3	NP_038462.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		FRQ1	81..245	CDD:227455	87/163 (53%)
		EFh	130..192	CDD:238008	34/61 (56%)
		EFh	166..238	CDD:238008	31/71 (44%)
		Interaction with KCND2. /evidence=ECO:0000250	243..256		4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143264
Domainoid	1	1.000	96	1.000	Domainoid score	I7327
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606780at33208
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	1	1.000	-	-		otm40506
orthoMCL	1	0.900	-	-		OOG6_101448
Panther	1	1.100	-	-	O	PTHR23055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5210
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.930