DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5890 and NCS1

DIOPT Version :9

Sequence 1:	NP_001356889.1	Gene:	CG5890 / 43126	FlyBaseID:	FBgn0039380	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_055101.2	Gene:	NCS1 / 23413	HGNCID:	3953	Length:	190	Species:	Homo sapiens

Alignment Length:	178	Identity:	70/178 - (39%)
Similarity:	114/178 - (64%)	Gaps:	0/178 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PVALEDLCRQTKFTKQEIRVMYRGFKTECPEGVVHEDCFKDIYAKFFPHGNSSLYAHYVFKAFDV 90
            |..:|:|.|:|.||::|::..|:||..:||.|.:....|:.||.:|||.|:.:.:|.:||..||.
Human    10 PEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDE 74

  Fly    91 NCNGAISFRDLLVTLSTLLRGSVYERLRWTFKLYDLNGDGRISRGELSEIILAIHELMGRRPHQP 155
            |.:|.|.|.:.:..||...||::.|:|||.||||||:.||.|:|.|:.:|:.||::::|.....|
Human    75 NKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELP 139

  Fly   156 EDDRKARDQVDRVFRKLDLNQDGIITIEEFLEACLKDDLVTRSLQMFD 203
            |::.....:|||:|..:|.|.||.:|::||.|....|..:.::|.::|
Human   140 EEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYD 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5890	NP_001356889.1	FRQ1	29..192	CDD:227455	66/162 (41%)
NCS1	NP_055101.2	FRQ1	20..179	CDD:227455	64/158 (41%)
NCS1	NP_055101.2	Interaction with IL1RAPL1. /evidence=ECO:0000269\|PubMed:12783849	174..190		3/14 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143246
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840