DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5886 and txlnba

DIOPT Version :9

Sequence 1:	NP_651435.1	Gene:	CG5886 / 43125	FlyBaseID:	FBgn0039379	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_005160864.1	Gene:	txlnba / 563018	ZFINID:	ZDB-GENE-030131-322	Length:	798	Species:	Danio rerio

Alignment Length:	541	Identity:	159/541 - (29%)
Similarity:	290/541 - (53%)	Gaps:	67/541 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SKAKKVAR---EEKQRDQKL-------EELVMKSLDECPSAEEKVKLLLQRHVDSEKNVSRLTAE 59
            |::|:||.   :|:..::||       ...:::||::..|.||||:::|:::       |.|..|
Zfish    71 SESKEVAAGADKEQNTEKKLLKGLGKEAASLLQSLNKLGSPEEKVEMVLKKY-------SELVDE 128

  Fly    60 LRVLQRQMES-QQR------EKEQVQRDLNKSVLMRDKLQEVCREQQRIIKSVKNESLLQIKVEE 117
            .|..::|:|. |||      :::|:|.:.::::|.|.||:.:|||.||..:::|.|||.:::.:|
Zfish   129 HRTEKKQLEQFQQRQGLLVKQRDQLQFEHSRAILARSKLETLCRELQRHNRTLKEESLQRLREDE 193

  Fly   118 ERRKESQTKFQSSLNDVQKSLAKNNEENIKLRDYNIEMTKKLKLLAEQYQTREQHLEKLNEQVQL 182
            .:|||..|.|||:|.|:|..:.:::..|.||...|.|:..|||.:.|||:.||:.|||:.:...|
Zfish   194 MKRKEITTHFQSTLVDIQSQIEQHSNRNNKLCKENSELAGKLKTIIEQYERREESLEKIFKHRDL 258

  Fly   183 EAQLHQAKLQKCQVEAAMEKEILSKENQIGLEKLMQAQRAIKDLTDREHQLKEQLNIYTAKYDDF 247
            :.:|..|||::..:.....:|...:|.:..|::.:...:....|.::|.|:|:||.:|:.|:|||
Zfish   259 QQKLSDAKLEEANMLLTQAEEKHKREKEYLLKEAIDKTKKYCTLREQELQMKKQLVLYSQKFDDF 323

  Fly   248 QQSLQKSNEVFGSYKVELEKMSKHTKKIEKEALGWRQKYEKANAMVIDLATEKSLQTQHSERLQK 312
            |.:|.||||::.::|.|::||:|..||:|||:..|:.::|..|..::::..|:|.:.:..|....
Zfish   324 QNTLAKSNEIYVTFKQEMDKMTKKMKKLEKESTTWKTRFESCNKALVEMIDERSEKGKEFELFTL 388

  Fly   313 QIQQLQKLLRALQLERTTLHKCLRDHE----------IEIP---ALPQLPPEPEPVNVKPVSAEN 364
            :|.:|:.|.||||.||.:|:..:::..          ::||   .||:|...|.|:    ::||
Zfish   389 KIDRLETLCRALQDERKSLYAKIKEIRFPEKMTAAPVVDIPPIDELPELVQTPNPM----LTAE- 448

  Fly   365 VKMEMMSRNCAELKQTLANLQNQMKLLTTNESKTSIEEKKK-------AEEQRQANNAKKNIRKK 422
              ||.:......|:...|:|.|.:..: ..||.:..|||:|       |:..:||:..:..   :
Zfish   449 --MEKLRAEQVRLQDFAASLLNPIPDV-AGESDSEDEEKEKDSPAIPEAQSIKQADQLEST---Q 507

  Fly   423 EKKSKAKAAAAAAAEAAASTTNGEANGVQESAATESKAELEAAGDASNVKNEKEQTVDIATDTQE 487
            |:.|..|     ..|...:.|..|    .:|...|: .:||:......:|:.::::..|.....|
Zfish   508 EQSSTTK-----VIEEKPTATKSE----MDSKLPEA-PQLESIKPVDQLKSTQDESSTIKVTITE 562

  Fly   488 LVGDGDAITAKSLVDISEVPP 508
            ......|.|.....  |::||
Zfish   563 KKPTSPATTKPDTE--SKIPP 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5886	NP_651435.1	Taxilin	22..328	CDD:286771	107/312 (34%)
txlnba	XP_005160864.1	Taxilin	97..404	CDD:286771	107/313 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579324
Domainoid	1	1.000	223	1.000	Domainoid score	I2500
eggNOG	1	0.900	-	-		E1_KOG1850
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D532685at33208
OrthoFinder	1	1.000	-	-		FOG0001051
OrthoInspector	1	1.000	-	-		otm25282
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.810