DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5886 and TXLNB

DIOPT Version :9

Sequence 1:	NP_651435.1	Gene:	CG5886 / 43125	FlyBaseID:	FBgn0039379	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_694967.3	Gene:	TXLNB / 167838	HGNCID:	21617	Length:	684	Species:	Homo sapiens

Alignment Length:	503	Identity:	152/503 - (30%)
Similarity:	270/503 - (53%)	Gaps:	56/503 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RDQKLEE-----------LVMKSLDECPSAEEKVKLLLQRH---VDSEKNVSRLTAELRVLQRQM 67
            ::||||:           |:|::|::..:.|||...|.:::   :|..:...:   :|::||::.
Human   129 KEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQK---KLKLLQKKQ 190

  Fly    68 ESQQREKEQVQRDLNKSVLMRDKLQEVCREQQRIIKSVKNESLLQIKVEEERRKESQTKFQSSLN 132
            ...|:||:|:|.:.::::|.|.||:.:|||.||..|::|.|:|.:.:.|||:|||..:.|||:|.
Human   191 VQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLT 255

  Fly   133 DVQKSLAKNNEENIKLRDYNIEMTKKLKLLAEQYQTREQHLEKLNEQVQLEAQLHQAKLQKCQVE 197
            |:|..:.:.:|.|:||...|.|:.:|||.:.:||:.||:||:|:.:..:|:.:|..|||::.|..
Human   256 DIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEM 320

  Fly   198 AAMEKEILSKENQIGLEKLMQAQRAIKDLTDREHQLKEQLNIYTAKYDDFQQSLQKSNEVFGSYK 262
            ....:|...:|.:..|.:..:.:...|.|.::|..|:.||.:|:.::::||.:|.||||||.::|
Human   321 MKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFK 385

  Fly   263 VELEKMSKHTKKIEKEALGWRQKYEKANAMVIDLATEKSLQTQHSERLQKQIQQLQKLLRALQLE 327
            .|::|.:|..||:||:...|:.::|..|..::|:..||:|:.:..|....:|.:|:.|.||||.|
Human   386 QEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEE 450

  Fly   328 RTTLHKCLRDHEI-EIPALPQLPPEPEPVNVKPVSAENVKMEMMSRNCAELKQTLANLQNQMKLL 391
            |..|||.:||.|| |.....|...:.|     |.|..:|..|:.:.....::..:.||.....::
Human   451 RNELHKKIRDAEISEKDDQSQHNSDEE-----PESNVSVDQEIDAEEVNSVQTAVKNLATAFMII 510

  Fly   392 -----TTNESKTSIEEKKKAEEQRQANNAKKN------IRKKEKKS-------KAKAAAAAAAEA 438
                 |.::||.:  :.:....|..|:.|.|.      |..::.:|       :|:|...:.||.
Human   511 HHPESTPHQSKET--QPEIGSSQESADAALKEPEQPPLIPSRDSESPLPPLTPQAEAEGGSDAEP 573

  Fly   439 AASTTNGEAN------------GVQESAATESKAELEAAGDASNVKNE 474
            .:..:|..|.            |.|...|: .|.|.||:|.|.....|
Human   574 PSKASNSPAGLGAETQCEGLPVGAQADQAS-WKPEAEASGQAPQAPTE 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5886	NP_651435.1	Taxilin	22..328	CDD:286771	106/319 (33%)
TXLNB	NP_694967.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..132		0/2 (0%)
		Taxilin	143..450	CDD:313024	105/309 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..485		9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..632		25/110 (23%)
		DNA_pol3_gamma3	<519..>683	CDD:331207	24/105 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..684
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145853
Domainoid	1	1.000	222	1.000	Domainoid score	I2596
eggNOG	1	0.900	-	-		E1_KOG1850
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3435
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D532685at33208
OrthoFinder	1	1.000	-	-		FOG0001051
OrthoInspector	1	1.000	-	-		otm41262
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860