DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4956 and AKR1

DIOPT Version :9

Sequence 1:	NP_651428.2	Gene:	CG4956 / 43114	FlyBaseID:	FBgn0039370	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_010550.1	Gene:	AKR1 / 851857	SGDID:	S000002672	Length:	764	Species:	Saccharomyces cerevisiae

Alignment Length:	403	Identity:	71/403 - (17%)
Similarity:	125/403 - (31%)	Gaps:	147/403 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 HRHFQLH------------RIKVMGLLHPF----CAIFLLCLIGLLFVYELCYVLPQITDP---- 71
            |..|..|            ..|::..:.||    .|..|...|..|||..:.::|...|:.
Yeast   302 HSGFDYHGYPIKKWFKKSQHAKLVTFITPFLFLGIAFALFSHINPLFVIIVLFLLAIATNKGLNK 366

  Fly    72 -----------HGI-----------------WHKLCWFMGI---------YT----VINILGNWW 95
                       |.:                 |..:.||..:         ||    ::.::..::
Yeast   367 FVLPSYGRMGVHNVTLLRSPLLSGVFFGTLLWVTIVWFFKVMPRTFSDEQYTNILMLVILVSVFY 431

  Fly    96 L---------GCMTNTS-------VDSLVLERQYPVAGEAHLWHYCSTCQKLVPPRSWHCSLCNI 144
            |         ||:...:       ..|.:||     .|:....::|.......|.||....|.|.
Yeast   432 LFGQLVIMDPGCLPEETDHENVRQTISNLLE-----IGKFDTKNFCIETWIRKPLRSKFSPLNNA 491

  Fly   145 CILKRDHHCTFFASCIGHKNQRYFLAFLFHLSFGSGQALVYNGILNWTNKAFLVVDPLLLMFQDT 209
            .:.:.||:|.:..:.:|.||.:.|:.|:         .|:.:||..:........|.|....:||
Yeast   492 VVARFDHYCPWIFNDVGLKNHKAFIFFI---------TLMESGIFTFLALCLEYFDELEDAHEDT 547

  Fly   210 TQ--------DADFKWKYTIANLFKLNLFLFGVPLFMFVFQMIMVYRNSTCYKMLDRSYDV---- 262
            :|        .|.......|.:.|...:.|:.:...::|..:|.|.....|..|.:..::|
Yeast   548 SQKNGKCFILGASDLCSGLIYDRFVFLILLWALLQSIWVASLIFVQAFQICKGMTNTEFNVLMKE 612

  Fly   263 ---------GWRRNFDMVLGKRRFWIFFSP----------TISSPLP-----------------T 291
                     .:..||:.....      |:|          |:.:|:|                 |
Yeast   613 SKSIGPDGLSFNENFNTTPEG------FAPSIDPGEESNDTVLAPVPGSTIRKPRTCFGVCYAVT 671

  Fly   292 DGTQWFQ--KQTV 302
            ...||..  |:|:
Yeast   672 GMDQWLAVIKETI 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4956	NP_651428.2	zf-DHHC	123..251	CDD:279823	29/135 (21%)
AKR1	NP_010550.1	ANK repeat	75..101	CDD:293786
		ANKYR	78..270	CDD:223738
		ANK repeat	103..140	CDD:293786
		ANK repeat	142..173	CDD:293786
		ANK repeat	213..244	CDD:293786
		ANK repeat	246..271	CDD:293786
		COG5273	363..725	CDD:227598	57/342 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810