DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4956 and Zdhhc17

DIOPT Version :9

Sequence 1:	NP_651428.2	Gene:	CG4956 / 43114	FlyBaseID:	FBgn0039370	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_001034429.1	Gene:	Zdhhc17 / 366889	RGDID:	1595790	Length:	622	Species:	Rattus norvegicus

Alignment Length:	345	Identity:	80/345 - (23%)
Similarity:	122/345 - (35%)	Gaps:	103/345 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RIKVMGLLHPFCAIFLLCLI-----------GLLF--VYELCYVLPQITDPHGI----------- 74
            |.||| |..||..|:|:..|           ||::  |:.....|.:....|.:
  Rat   292 RQKVM-LGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLA 355

  Fly    75 ---WHKLCWFMGIYTVINIL-----------------GNWWL---GCMTNTSVDSLVLERQYPVA 116
               |..:.||...:..::.|                 |..|.   |.:..|.........:....
  Rat   356 TKFWMYVTWFFWFWNDLSFLSIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAET 420

  Fly   117 GEAHLWHYCSTCQKLVPPRSWHCSLCNICILKRDHHCTFFASCIGHKNQRYFLAFLFHLSFGSGQ 181
            |...|..:||||....|.||.||.:||.||.|.||||.:..:|:...|.|||:.:||.|.|....
  Rat   421 GSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVCAGNHRYFMGYLFFLLFMICW 485

  Fly   182 ALVYNGILNWTNKAFLVVDPLLLMFQDTTQDADFKWKY----TIANLFKLNLFLFGVPLFMFVFQ 242
             ::|..:..|.            :..:||...|..|.|    ...:.:...:||..|..||:|..
  Rat   486 -MIYGCVSYWG------------LHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAV 537

  Fly   243 MIM--VYR------------NSTCYK-------MLDRSYDVGWRRN----FDMVLGKRRFWIFFS 282
            ::|  :|:            |:..||       .::..::.|..||    |:.     |....|.
  Rat   538 LLMCQMYQITCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEF-----RCCGLFR 597

  Fly   283 PTISSPLPTDGTQWFQKQTV 302
            |.|        ..|.::.|:
  Rat   598 PVI--------VDWTRQYTI 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4956	NP_651428.2	zf-DHHC	123..251	CDD:279823	43/145 (30%)
Zdhhc17	NP_001034429.1	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250\|UniProtKB:Q80TN5	1..295		1/2 (50%)
		Ank_4	<60..100	CDD:290365
		ANK	77..192	CDD:238125
		ANK repeat	79..110	CDD:293786
		Ank_2	84..177	CDD:289560
		ANK repeat	112..144	CDD:293786
		ANK	143..267	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_2	151..245	CDD:289560
		ANK repeat	179..211	CDD:293786
		ANK repeat	214..245	CDD:293786
		zf-DHHC	428..558	CDD:279823	42/142 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810