DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4956 and ZDHHC5

DIOPT Version :9

Sequence 1:	NP_651428.2	Gene:	CG4956 / 43114	FlyBaseID:	FBgn0039370	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_056272.2	Gene:	ZDHHC5 / 25921	HGNCID:	18472	Length:	715	Species:	Homo sapiens

Alignment Length:	299	Identity:	70/299 - (23%)
Similarity:	108/299 - (36%)	Gaps:	94/299 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 AIFLLCLIGLLFVYELC-----YVLPQITDPHGIWHKLCWFMGIYTVINILGNWWLGCMTNTSVD 105
            ||||:....|.|.: .|     ||.|.:.              ||..|     .:|..:.|.|:.
Human    21 AIFLVGATTLFFAF-TCPGLSLYVSPAVP--------------IYNAI-----MFLFVLANFSMA 65

  Fly   106 SLVLERQYPVAGE---------AHLW------------HYCSTCQKLVPPRSWHCSLCNICILKR 149
            :.:....:|.|.|         |.|:            .:|:||:...|||..|||:|:.|:.:.
Human    66 TFMDPGIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEF 130

  Fly   150 DHHCTFFASCIGHKNQRYFLAFLFHLS------FGSGQALVYNGILNWTNKAFLVVDPLLLMFQD 208
            ||||.:..:|||.:|.|||..||..|:      ||.|                     ||.:...
Human   131 DHHCPWVNNCIGRRNYRYFFLFLLSLTAHIMGVFGFG---------------------LLYVLYH 174

  Fly   209 TTQDADFKWKYTIANLFKLNLFLFGVPLF-MFVFQMIMVYRNSTCYKMLD-------RSYDVGWR 265
            ..:.:..:...|:|.:....||.  :|:. :..|.:::|.|..|..:.:.       ..:..|..
Human   175 IEELSGVRTAVTMAVMCVAGLFF--IPVAGLTGFHVVLVARGRTTNEQVTGKFRGGVNPFTNGCC 237

  Fly   266 RNFDMVL-----------GKRRFWIFFSPTISSPLPTDG 293
            .|...||           .|:...|...|....|..:||
Human   238 NNVSRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDG 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4956	NP_651428.2	zf-DHHC	123..251	CDD:279823	38/134 (28%)
ZDHHC5	NP_056272.2	DHHC	99..224	CDD:366691	39/147 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..715
		DUF4671	594..>704	CDD:374041
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810