DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4956 and ZDHHC23

DIOPT Version :9

Sequence 1:	NP_651428.2	Gene:	CG4956 / 43114	FlyBaseID:	FBgn0039370	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_001307395.1	Gene:	ZDHHC23 / 254887	HGNCID:	28654	Length:	435	Species:	Homo sapiens

Alignment Length:	178	Identity:	48/178 - (26%)
Similarity:	79/178 - (44%)	Gaps:	34/178 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 YCSTCQKLVPPRSWHCSLCNICILKRDHHCTFFASCIGHKN-QRYFLAFL-FHLSFGSGQALVYN 186
            :|:.||.:.|.|:|||.:|.||:.:.||||.:..||:|..| |.:.||.| |.|:...|..|..:
Human   260 WCAKCQLVRPARAWHCRICGICVRRMDHHCVWINSCVGESNHQAFILALLIFLLTSVYGITLTLD 324

  Fly   187 GILNWTNKAFLVVDPLLLMFQDTTQDADFK--WKYTIANLFKLNLFLFGVPLFMFVFQMIMVYRN 249
            .|.. ....|..:.....::.:.:....|.  | |::       :...|: .::|:.|:|.:..|
Human   325 TICR-DRSVFTALFYCPGVYANYSSALSFTCVW-YSV-------IITAGM-AYIFLIQLINISYN 379

  Fly   250 ST-----------------CYKMLDR-SYDVGWRRNFDM--VLGKRRF 277
            .|                 |..::|. .|:.|:.||:..  .||.|.|
Human   380 VTEREVQQALRQKTGRRLLCGLIVDTGQYNRGFLRNWHQFSTLGTRAF 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4956	NP_651428.2	zf-DHHC	123..251	CDD:279823	37/130 (28%)
ZDHHC23	NP_001307395.1	MerC	96..>151	CDD:281231
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..255
		zf-DHHC	258..384	CDD:279823	38/133 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810