DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4956 and ZDHHC15

DIOPT Version :9

Sequence 1:	NP_651428.2	Gene:	CG4956 / 43114	FlyBaseID:	FBgn0039370	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_659406.1	Gene:	ZDHHC15 / 158866	HGNCID:	20342	Length:	337	Species:	Homo sapiens

Alignment Length:	301	Identity:	74/301 - (24%)
Similarity:	116/301 - (38%)	Gaps:	90/301 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PFCAIFLLCLIG-LLFVYELCYVLPQITDPHGIWHKLCWFMGIYTVINILGNW--WLGCMT---- 100
            |...|.|:.|.. ..:|:|||.|  .:..|.   .|:.:.: :|..|.:...|  |....|
Human    24 PVLVIVLVVLWSYYAYVFELCLV--TVLSPA---EKVIYLI-LYHAIFVFFTWTYWKSIFTLPQQ 82

  Fly   101 ---------------------NTSVDSLV-LERQYPV---AGEAHLWHYCSTCQKLVPPRSWHCS 140
                                 ......|| :.::.||   .|...: .:|..|..:.|.|..|||
Human    83 PNQKFHLSYTDKERYENEERPEVQKQMLVDMAKKLPVYTRTGSGAV-RFCDRCHLIKPDRCHHCS 146

  Fly   141 LCNICILKRDHHCTFFASCIGHKNQRYFLAFLFHLSFGSGQALVYNGILNWTNKAFLVVDPLLLM 205
            :|.:|:||.||||.:..:|||..|.::||.||                      |:.|   |..:
Human   147 VCAMCVLKMDHHCPWVNNCIGFSNYKFFLQFL----------------------AYSV---LYCL 186

  Fly   206 FQDTTQDADF--KWK---YTIANLFKLNLFLFGVPLFMFVFQMI-------MVYRNSTCYKML-- 256
            :..||..:.|  .|:   .::.:.|.: |||..|....||..:|       :|.||.|..:..
Human   187 YIATTVFSYFIKYWRGELPSVRSKFHV-LFLLFVACMFFVSLVILFGYHCWLVSRNKTTLEAFCT 250

  Fly   257 --------DRSYDVGWRRNFDMVLG-KRRFWIFFSPTISSP 288
                    ...:::|:.:|...|.| |::||:.  |..|||
Human   251 PVFTSGPEKNGFNLGFIKNIQQVFGDKKKFWLI--PIGSSP 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4956	NP_651428.2	zf-DHHC	123..251	CDD:279823	41/139 (29%)
ZDHHC15	NP_659406.1	zf-DHHC	<126..308	CDD:327686	53/193 (27%)
ZDHHC15	NP_659406.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..337
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810