DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17195 and AKR1

DIOPT Version :9

Sequence 1:	NP_651427.2	Gene:	CG17195 / 43113	FlyBaseID:	FBgn0039369	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_010550.1	Gene:	AKR1 / 851857	SGDID:	S000002672	Length:	764	Species:	Saccharomyces cerevisiae

Alignment Length:	262	Identity:	54/262 - (20%)
Similarity:	98/262 - (37%)	Gaps:	78/262 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VHPLSIV-FVLCSTAFFFSL------QMFYIAPKVFGDIAYKLYWILVTFIT-HNILGNML---- 75
            ||.:::: ..|.|..||.:|      ..|.:.|:.|.|..|....:||..:: ..:.|.::
Yeast   377 VHNVTLLRSPLLSGVFFGTLLWVTIVWFFKVMPRTFSDEQYTNILMLVILVSVFYLFGQLVIMDP 441

  Fly    76 ACY----------MTSSSVNTLSK-DSRCPNPEDEPLWHYC-ESCKKLRSP-RSWHCVLCNTCIL 127
            .|.          .|.|::..:.| |::          ::| |:.  :|.| ||....|.|..:.
Yeast   442 GCLPEETDHENVRQTISNLLEIGKFDTK----------NFCIETW--IRKPLRSKFSPLNNAVVA 494

  Fly   128 RRDHHCIFTGTCIGHNNQRFFFWFTFYLTLGLVTSFATFCMFIL------------QNGGNF-MS 179
            |.||:|.:....:|..|.:.|.:|...:..|:.| |...|:...            :||..| :.
Yeast   495 RFDHYCPWIFNDVGLKNHKAFIFFITLMESGIFT-FLALCLEYFDELEDAHEDTSQKNGKCFILG 558

  Fly   180 LSSVIFNLITRTFFQNYTGNTFETIAFLLNI----------SASYMPAFMLAYQMQILSQNSTYY 234
            .|.:...||            ::...||:.:          |..::.||.:...|     .:|.:
Yeast   559 ASDLCSGLI------------YDRFVFLILLWALLQSIWVASLIFVQAFQICKGM-----TNTEF 606

  Fly   235 NI 236
            |:
Yeast   607 NV 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17195	NP_651427.2	zf-DHHC	103..234	CDD:279823	33/155 (21%)
AKR1	NP_010550.1	ANK repeat	75..101	CDD:293786
		ANKYR	78..270	CDD:223738
		ANK repeat	103..140	CDD:293786
		ANK repeat	142..173	CDD:293786
		ANK repeat	213..244	CDD:293786
		ANK repeat	246..271	CDD:293786
		COG5273	363..725	CDD:227598	54/262 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810