DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17195 and ZDHHC1

DIOPT Version :9

Sequence 1:	NP_651427.2	Gene:	CG17195 / 43113	FlyBaseID:	FBgn0039369	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_037436.1	Gene:	ZDHHC1 / 29800	HGNCID:	17916	Length:	485	Species:	Homo sapiens

Alignment Length:	259	Identity:	62/259 - (23%)
Similarity:	91/259 - (35%)	Gaps:	76/259 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 HPLSIVFVLCSTAFFFSLQMFYIAPKVFGDIAYKLYWILVTFITHN-----------ILGNMLAC 77
            |||.||..|        |.:|:   .|.|      :.|||..:.|:           |....|..
Human    49 HPLQIVAWL--------LYLFF---AVIG------FGILVPLLPHHWVPAGYACMGAIFAGHLVV 96

  Fly    78 YMTSSSV-----NTLSKDSRCPNPEDEPLWH-------YCESCKKLRSPRSWHCVLCNTCILRRD 130
            ::|:.|:     |...|....|.|......|       :|..|....|.||.||..||.|:...|
Human    97 HLTAVSIDPADANVRDKSYAGPLPIFNRSQHAHVIEDLHCNLCNVDVSARSKHCSACNKCVCGFD 161

  Fly   131 HHCIFTGTCIGHNNQRFFFWFTFYLTLG-----LVTSFATFCMFILQNGGNFMSLSSVIFNLITR 190
            |||.:...|:|..|.|.|........||     ||.::.....|:     |.|.|.:      .|
Human   162 HHCKWLNNCVGERNYRLFLHSVASALLGVLLLVLVATYVFVEFFV-----NPMRLRT------NR 215

  Fly   191 TF--FQNYTGNTF--------ET----------IAFLLNISASYMPAFMLAYQMQILSQNSTYY 234
            .|  .:|:|...|        ||          :..||.:.::.:...:|.:.:.::....|.|
Human   216 HFEVLKNHTDVWFVFLPAAPVETQAPAILALAALLILLGLLSTALLGHLLCFHIYLMWHKLTTY 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17195	NP_651427.2	zf-DHHC	103..234	CDD:279823	39/162 (24%)
ZDHHC1	NP_037436.1	Mediates interaction with STING1. /evidence=ECO:0000269\|PubMed:25299331	1..271		60/249 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		zf-DHHC	129..284	CDD:307600	39/162 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..358
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810