DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17196 and Zdhhc17

DIOPT Version :9

Sequence 1:	NP_651426.1	Gene:	CG17196 / 43112	FlyBaseID:	FBgn0039368	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_766142.2	Gene:	Zdhhc17 / 320150	MGIID:	2445110	Length:	632	Species:	Mus musculus

Alignment Length:	260	Identity:	66/260 - (25%)
Similarity:	117/260 - (45%)	Gaps:	41/260 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AVSIGHPLSVIFLLVSTVFFFTLQVFYVAPDVHDGFMYKFFVISAIFTTYNILGNLLACYRTSSA 83
            |:.:|..|:..|.:..|.||:    |:  .|::..|::..|:.:::...|| .|.   .:::...
Mouse   357 ALPLGIYLATKFWMYVTWFFW----FW--NDLNFLFIHLPFLANSVALFYN-FGK---SWKSDPG 411

  Fly    84 VKSLPQER------QIPKPGTEHLWHYCDICQKLMPPRSWHCALCKCCILKRDHHCIFAATCIGH 142
            :....:|:      ::.:.|:..|..:|..|....|.||.||.:|..||.|.||||.:...|:|.
Mouse   412 IIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGA 476

  Fly   143 NNHRYFFWLTFYLAFGIFMSMATLFVDVGRSFYLLH----RMKAGFGNTVKSL---SYFRYVCLI 200
            .|||||..   ||.|.:||....::..|  |::.||    ..|.||...:..:   |.:.:...:
Mouse   477 GNHRYFMG---YLFFLLFMICWMIYGCV--SYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFL 536

  Fly   201 LNIFALGFPALMLRFQVQILKLNSTYYQISSRHHDLGFRNNCQLIMGQRGLWTFISPSLRSPLPH 265
            .::|...:.|::|..|:         |||:.    ||...|.::...:...:...:.|:.||..|
Mouse   537 NSVFHFLWVAVLLMCQL---------YQITC----LGITTNERMNARRYKHFKVTTTSIESPFNH 588

Fly 266 265
Mouse 589 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17196	NP_651426.1	zf-DHHC	103..228	CDD:279823	39/131 (30%)
Zdhhc17	NP_766142.2	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000269\|PubMed:25253725	11..305
		ANK repeat	89..120	CDD:293786
		PHA03095	100..>352	CDD:222980
		ANK repeat	122..154	CDD:293786
		ANK repeat	156..187	CDD:293786
		Ank_2	161..255	CDD:372319
		ANK repeat	189..221	CDD:293786
		ANK repeat	224..255	CDD:293786
		DHHC	438..568	CDD:366691	45/147 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810